[1]黄玥晔,曲伸.甲状腺激素受体:非酒精性脂肪性肝病的新靶点[J].国际内分泌代谢杂志,2014,(01):43-45.[doi:10.3760/cma.j.issn.1673-4157.2014.01.012]
 Huang Yueye,Qu Shen.Thyroid hormone receptor:a new target of nonalcoholic fatty liver disease[J].International Journal of Endocrinology and Metabolism,2014,(01):43-45.[doi:10.3760/cma.j.issn.1673-4157.2014.01.012]
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甲状腺激素受体:非酒精性脂肪性肝病的新靶点()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年01期
页码:
43-45
栏目:
综述
出版日期:
2014-02-28

文章信息/Info

Title:
Thyroid hormone receptor:a new target of nonalcoholic fatty liver disease
作者:
黄玥晔曲伸
200072 上海同济大学附属第十人民医院内分泌代谢科   
Author(s):
Huang YueyeQu Shen.
Department of Endocrinology and Metabolism,Shanghai 10th People's Hospital,School of Medicine,Tongji University,Shanghai 200072,China Corresponding author:Qu Shen,Email:qushencn@hotmail.com
关键词:
甲状腺激素甲状腺激素受体非酒精性脂肪性肝病肥胖
Keywords:
Thyroid hormoneThyroid hormone receptorNonalcoholic fatty liver diseaseObesity
DOI:
10.3760/cma.j.issn.1673-4157.2014.01.012
摘要:
甲状腺激素(TH)是维持正常代谢的重要激素,甲状腺激素受体(TR)及其亚型的分布在不同组织起着不同的作用,其中TRβ参与了脂代谢并主要作用于肝脏。 TH与高血脂、肥胖、胰岛素抵抗及非酒精性脂肪性肝病(NAFLD)的发生密不可分。 TR?琢抑制剂、TRβ激动剂及TH类似物均显示出了对NAFLD 的治疗作用。
Abstract:
Thyroid hormone(TH) is an important hormone for maintaining normal metabolism,thyroid hormone receptor(TR) and its isoforms distribute in different tissues with different effects.TRβ acts mainly in liver and participates in lipid metabolism.TH is closely associated with hyperlipemia,obesity,insulin resistance and nonalcoholic fatty liver disease(NAFLD).TR?琢 antagonist,TRβ agonist and TH analogue show therapeutic effects of NAFLD.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81070238);中华医学会临床医学科研专项资金(12020550355) 通信作者:曲伸,Email:qushencn@hotmail.com
更新日期/Last Update: 2014-01-20