[1]张亦涵,徐浣白.雌激素及其信号通路与甲状腺乳头状癌关系的研究进展[J].国际内分泌代谢杂志,2023,43(03):225-228.[doi:10.3760/cma.j.cn121383-20220501-05001]
　Zhang Yihan,Xu Huanbai..Clinical features and role of estrogen/estrogen receptor in papillary thyroid carcinoma in women[J].International Journal of Endocrinology and Metabolism,2023,43(03):225-228.[doi:10.3760/cma.j.cn121383-20220501-05001]
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雌激素及其信号通路与甲状腺乳头状癌关系的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年03期
页码:
225-228
栏目:
综述
出版日期:
2023-05-20

文章信息/Info

Title:
Clinical features and role of estrogen/estrogen receptor in papillary thyroid carcinoma in women
作者:
张亦涵; 徐浣白
上海交通大学医学院附属第一人民医院内分泌代谢科,上海 200080
Author(s):
Zhang Yihan;  Xu Huanbai.
Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
关键词:
女性;  甲状腺乳头状癌;  雌激素;  雌激素受体
Keywords:
Woman;  Papillary thyroid carcinoma;  Estrogen;  Estrogen receptor
DOI:
10.3760/cma.j.cn121383-20220501-05001
摘要:
甲状腺乳头状癌(PTC)在女性中有较高的发病率,且女性PTC发病率受年龄等因素影响,这提示雌激素/雌激素受体(ERs)在PTC中发挥独特作用,多数研究证明ERα表达与PTC成正相关性,而ERβ与PTC发生呈负相关。且在PTC进程中雌激素可对ERs表达及肿瘤微环境造成影响。调控雌激素/ERs在PTC中的表达已经成为雌激素相关肿瘤治疗中重要的一部分。分析PTC女性发病的特点,探索不同ERs在甲状腺肿瘤中的作用,可为治疗疾病提供新的思路。
Abstract:
Papillary thyroid carcinoma(PTC)has a high incidence rate in women, and is affected by age, menopause and other factors. Estrogen receptors(ERs)play a unique role in PTC. In this paper, ERs is discussed more specifically. Most studies have demonstrated a positive correlation between ERα expression with PTC. Most studies have shown that ERβ is negatively correlated with PTC. Estrogen can affect ERs expression and tumor microenvironment during PTC process. Regulation of estrogen/ERs expression in PTC has become an important part in the treatment of estrogen-associated tumors. To analyze the characteristics of female incidence in PTC and explore the role of different ERs in thyroid tumors may provide new ideas for the treatment of the disease.

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备注/Memo

备注/Memo:
通信作者:徐浣白,Email: huanbaixu@126.com
更新日期/Last Update: 2023-05-20