[1]文婧怡,郭立新.急性高糖诱发肾小管相关白蛋白尿的发病机制[J].国际内分泌代谢杂志,2022,42(03):195-198.[doi:10.3760/cma.j.cn121383-20210302-03003]
 Wen Jingyi,Guo Lixin..Pathogenesis of acute hyperglycemia-induced renal tubular-associated albuminuria[J].International Journal of Endocrinology and Metabolism,2022,42(03):195-198.[doi:10.3760/cma.j.cn121383-20210302-03003]
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急性高糖诱发肾小管相关白蛋白尿的发病机制()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年03期
页码:
195-198
栏目:
综述
出版日期:
2022-05-20

文章信息/Info

Title:
Pathogenesis of acute hyperglycemia-induced renal tubular-associated albuminuria
作者:
文婧怡郭立新
北京协和医学院研究生院 100730; 北京医院内分泌科,国家老年医学中心,中国医学科学院老年医学研究院 100730
Author(s):
Wen Jingyi Guo Lixin.
Graduate School of Peking Union Medical College, Beijing 100730, China; Department of Endocrinology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, P.R. China, Beijing 100730, China
关键词:
肾小管 糖尿病肾脏病 微量白蛋白尿 急性高糖
Keywords:
Renal tubule Diabetic kidney disease Microalbuminuria Acute hyperglycemia
DOI:
10.3760/cma.j.cn121383-20210302-03003
摘要:
近期研究发现肾小管功能和结构异常在糖尿病肾脏病(DKD)所导致的微量白蛋白尿的发病机制中发挥重要作用。血糖控制不佳是糖尿病患者出现微量白蛋白尿的一个重要因素。急性高糖通过各种途径诱发肾小管功能障碍可能是糖尿病早期微量白蛋白尿的潜在发病机制之一。
Abstract:
Recent studies have shown that abnormal function and structure of renal tubules play important roles in the pathogenesis of microalbuminuria caused by diabetic kidney disease(DKD). Poor blood glucose control is known to be an important risk factor of the occurrence of microalbuminuria in diabetic patients. Renal tubular dysfunction induced by acute hyperglycemia may be one of the potential pathogenesis of microalbuminuria in early-stage diabetes.

参考文献/References:

[1] Hemmelgarn BR,Manns BJ,Lloyd A,et al.Relation between kidney function,proteinuria,and adverse outcomes[J].JAMA,2010,303(5):423-429.DOI:10.1001/jama.2010.39.
[2] Looker HC,Mauer M,Saulnier PJ,et al.Changes in albuminuria but not GFR are associated with early changes in kidney structure in type 2 diabetes[J].J Am Soc Nephrol,2019,30(6):1049-1059.DOI:10.1681/ASN.2018111166.
[3] Tong X,Yu Q,Ankawi G,et al.Insights into the Role of Renal Biopsy in Patients with T2DM:A Literature Review of Global Renal Biopsy Results[J].Diabetes Ther,2020,11(9):1983-1999.DOI:10.1007/s13300-020-00888-w.
[4] Wang JY,Yang JH,Xu J,et al.Renal tubular damage may contribute more to acute hyperglycemia induced kidney injury in non-diabetic conscious rats[J].J Diabetes Complications,2015,29(5):621-628.DOI:10.1016/j.jdiacomp.2015.04.014.
[5] Sharma SG,Bomback AS,Radhakrishnan J,et al.The modern spectrum of renal biopsy findings in patients with diabetes[J].Clin J Am Soc Nephrol,2013,8(10):1718-1724.DOI:10.2215/CJN.02510213.
[6] Ekinci EI,Jerums G,Skene A,et al.Renal structure in normoalbuminuric and albuminuric patients with type 2 diabetes and impaired renal function[J].Diabetes Care,2013,36(11):3620-3626.DOI:10.2337/dc12-2572.
[7] Maezawa Y,Takemoto M,Yokote K.Cell biology of diabetic nephropathy:roles of endothelial cells,tubulointerstitial cells and podocytes[J].J Diabetes Invest,2015,6(1):3-15.DOI:10.1111/jdi.12255.
[8] Zerbini G,Bonfanti R,Meschi F,et al.Persistent renal hypertrophy and faster decline of glomerular filtration rate precede the development of microalbuminuria in type 1 diabetes[J].Diabetes,2006,55(9):2620-2625.DOI:10.2337/db06-0592.
[9] Vallon V,Thomson SC.Renal function in diabetic disease models:the tubular system inthe pathophysiology of the diabetic kidney[J].Annu Rev Physiol,2012,74:351-375.DOI:10.1146/annurev-physiol-020911-153333.
[10] An Y,Xu F,Le W,et al.Renal histologic changes and the outcome in patients with diabetic nephropathy[J].Nephrol Dial Transplant,2015,30(2):257-266.DOI:10.1093/ndt/gfu250.
[11] Mise K,Hoshino J,Ueno T,et al.Clinical and pathological predictors of estimated GFR decline in patients with type 2 diabetes and overt proteinuric diabetic nephropathy[J].Diabetes Metab Res Rev,2015,31(6):572-581.DOI:10.1002/dmrr.2633.
[12] Vaidya VS,Niewczas MA,Ficociello LH,et al.Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers,kidney injury molecule-1,and N-acetyl-β-D-glucosaminidase[J].Kidney Int,2011,79(4):464-470.DOI:10.1038/ki.2010.404.
[13] Nauta FL,Boertien WE,Bakker SJ,et al.Glomerular and tubular damage markers are elevated in patients with diabetes[J].Diabetes Care,2011,34(4):975-981.DOI:10.2337/dc10-1545.
[14] Comper WD.Albuminuria is controlled primarily by proximal tubules[J].Nat Rev Nephrol,2014,10(3):180.DOI:10.1038/nrneph.2013.58-c1.
[15] Wagner MC,Campos-Bilderback SB,Chowdhury M,et al.Proximal tubules have the capacity to regulate uptake of albumin[J].J Am Soc Nephrol,2016,27(2):482-494.DOI:10.1681/ASN.2014111107.
[16] Desideri S,Onions KL,Qiu Y,et al.A novel assay provides sensitive measurement of physiologically relevant changes in albumin permeability in isolated human and rodent glomeruli[J].Kidney Int,2018,93(5):1086-1097.DOI:10.1016/j.kint.2017.12.003.
[17] Russo LM,Sandoval RM,McKee M,et al.The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells:retrieval is disrupted in nephrotic states[J].Kidney Int,2007,71(6):504-513.DOI:10.1038/sj.ki.5002041.
[18] Christensen EI,Birn H.Proteinuria:Tubular handling of albumin-degradation or salvation?[J].Nat Rev Nephrol,2013,9(12):700-702.DOI:10.1038/nrneph.2013.212.
[19] Tenten V,Menzel S,Kunter U,et al.Albumin is recycled from the primary urine by tubular transcytosis[J].J Am Soc Nephrol,2013,24(12):1966-1980.DOI:10.1681/ASN.2013010018.
[20] Ren Q,Weyer K,Rbaibi Y,et al.Distinct functions of megalin and cubilin receptors in recovery of normal and nephrotic levels of filtered albumin[J].Am J Physiol Renal Physiol,2020,318(5):F1284-F1294.DOI:10.1152/ajprenal.00030.2020.
[21] Grove KJ,Lareau NM,Voziyan PA,et al.Imaging mass spectrometry reveals direct albumin fragmentation within the diabetic kidney[J].Kidney Int,2018,94(2):292-302.DOI:10.1016/j.kint.2018.01.040.
[22] Tojo A,Onozato ML,Ha H,et al.Reduced albumin reabsorption in the proximal tubule of early-stage diabetic rats[J].Histochem Cell Biol,2001,116(3):269-276.DOI:10.1007/s004180100317.
[23] Peres GB,Juliano MA,Simoes MJ,et al.Lysosomal enzymes are decreased in the kidney of diabetic rats[J].Biochim Biophys Acta,2013,1832(1):85-95.DOI:10.1016/j.bbadis.2012.09.011.
[24] Russo LM,Brammar GC,Jerums G,et al.The effect of ramipril on albumin excretion in diabetes and hypertension:the role of increased lysosomal activity and decreased transforming growth factor-beta expression[J].J Hypertens,2003,21(2):419-428.DOI:10.1097/00004872-200302000-00035.
[25] Russo LM,Sandoval RM,Campos SB,et al.Impaired tubular uptake explains albuminuria in early diabetic nephropathy[J].J Am Soc Nephrol,2009,20(3):489-494.DOI:10.1681/ASN.2008050503.
[26] Peruchetti DB,Silva-Aguiar RP,Siqueira GM,et al.High glucose reduces megalin-mediated albumin endocytosis in renal proximal tubule cells through protein kinase B O-GlcNAcylation[J].J Biol Chem,2018,293(29):11388-11400.DOI:10.1074/jbc.RA117.001337.
[27] Zhou L,Liu F,Huang XR,et al.Amelioration of albuminuria in ROCK1 knockout mice with streptozotocin-induced diabetic kidney disease[J].Am J Nephrol,2011,34(5):468-475.DOI:10.1159/000332040.
[28] Hall AM,Unwin RJ.The not so 'mighty chondrion':emergence of renal diseases due to mitochondrial dysfunction[J].Nephron Physiol,2007,105(1):1-10.DOI:10.1159/000096860.
[29] Navarro-González JF,Mora-Fernández C,Muros de Fuentes M,et al.Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy[J].Nat Rev Nephrol,2011,7(6):327-340.DOI:10.1038/nrneph.2011.51.
[30] Rosca MG,Vazquez EJ,Chen Q,et al.Oxidation of fatty acids is the source of increased mitochondrial reactive oxygen species production in kidney cortical tubules in early diabetes[J].Diabetes,2012,61(8):2074-2083.DOI:10.2337/db11-1437.
[31] Samikkannu T,Thomas JJ,Bhat GJ,et al.Acute effect of high glucose on long-term cell growth:a role for transient glucose increase in proximal tubule cell injury[J].Am J Physiol Renal Physiol,2006,291(1):F162-175.DOI:10.1152/ajprenal.00189.2005.
[32] Qiu YY,Tang LQ.Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy[J].Pharmacol Res,2016,114:251-264.DOI:10.1016/j.phrs.2016.11.004.
[33] Wang S,Li Y,Fan J,et al.Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation[J].Cell Death Dis,2017,8(7):e2937.DOI:10.1038/cddis.2017.292.
[34] Clavant SP,Forbes JM,Thallas V,et al.Reversible angiotensin II-mediated albuminuria in rat kidneys is dynamically associated with cytoskeletal organization[J].Nephron Physiol,2003,93(2):p51-60.DOI:10.1159/000068528.
[35] Feliers D,Kasinath BS.Mechanism of VEGF expression by high glucose in proximal tubule epithelial cells[J].Mol Cell Endocrinol,2010,314(1):136-142.DOI:10.1016/j.mce.2009.09.009.
[36] Tojo A,Onozato ML,Kurihara H,et al.Angiotensin II blockade restores albumin reabsorption in the proximal tubules of diabetic rats[J].Hypertens Res,2003,26(5):413-419.DOI:10.1291/hypres.26.413.
[37] Nilsson LM,Zhang L,Bondar A,et al.Prompt apoptotic response to high glucose in SGLT-expressing renal cells[J].Am J Physiol Renal Physiol,2019,316(5):F1078-F1089.DOI:10.1152/ajprenal.00615.2018.
[38] Zhang XQ,Dong JJ,Cai T,et al.High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells[J].Oncotarget,2017,8(15):24119-24129.DOI:10.18632/oncotarget.15491.

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备注/Memo

备注/Memo:
通信作者:郭立新,Email:glx1218@163.com
更新日期/Last Update: 2022-05-10