[1]乔晓玲,郗光霞.遗传学因素对2型糖尿病第一时相胰岛素分泌的影响[J].国际内分泌代谢杂志,2021,41(03):216-219.[doi:10.3760/cma.j.cn121383-20200812-08024]
 Qiao Xiaoling,Xi Guangxia..Effect of genetic factors on first-phase insulin secretion in patients with type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2021,41(03):216-219.[doi:10.3760/cma.j.cn121383-20200812-08024]
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遗传学因素对2型糖尿病第一时相胰岛素分泌的影响()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年03期
页码:
216-219
栏目:
综述
出版日期:
2021-05-20

文章信息/Info

Title:
Effect of genetic factors on first-phase insulin secretion in patients with type 2 diabetes mellitus
作者:
乔晓玲郗光霞
山西医科大学附属白求恩医院内分泌科,太原 030032
Author(s):
Qiao Xiaoling Xi Guangxia.
Bethune Hospital Affiliated to Shanxi Medical University, Taiyuan 030032, China
关键词:
基因变异 表观遗传学 第一时相胰岛素分泌 2型糖尿病
Keywords:
Genetic variation Epigenetics First-phase insulin secretion Type 2 diabetes mellitus
DOI:
10.3760/cma.j.cn121383-20200812-08024
摘要:
第一时相胰岛素分泌下降或缺失是2型糖尿病β细胞功能障碍的病理生理学特点,基因变异及表观遗传学改变影响第一时相胰岛素分泌。β细胞膜上ATP敏感钾通道(K+ATP)、L型钙通道及胰岛素胞吐基因变异降低第一时相胰岛素分泌。K+ATP通道调节蛋白基因变异一方面通过降低K+ATP亚基磺酰脲类受体1(SUR1)或内向整流钾通道(Kir6.2)水平,另一方面使K+ATP关闭障碍降低第一时相胰岛素分泌; β细胞膜L型钙通道调节蛋白基因变异通过降低L型钙通道活性或数量使第一时相胰岛素分泌下降; 胞吐相关基因突变通过降低质膜停靠的胰岛素颗粒数量,减少囊泡融合及释放,进而降低第一时相胰岛素分泌。此外,DNA甲基化改变、组蛋白乙酰化修饰及miRNA表达异常等表观遗传学改变通过影响胰岛素胞吐蛋白表达减少第一时相胰岛素分泌。
Abstract:
The decrease or loss of first-phase insulin secretion is the pathophysiological feature of β-cell dysfunction in type 2 diabetes. Genetic variations and epigenetic changes can affect the first-phase insulin secretion. The decreased first-phase insulin secretion results from genetic variations in ATP-sensitive potassium channels(K+ATP), L-type calcium channels in β-cell membrane and insulin exocytosis. The genetic variations in K+ATP channels regulators reduce the first-phase insulin secretion duing to the decreased level of sulfonylurea receptor 1(SUR1)or inward rectifier potassium channel(Kir6.2)subunit duing to the impairment of K+ATP closure; the genetic variations regulating L-type calcium channels in β-cell membrane decrease the first-phase insulin secretion by reducing the activity or number of L-type calcium channels. Exocytosis-related gene mutations reduce the first-phase insulin secretion by reducing the number of insulin granules docked in the plasma membrane and reducing the fusion and release of vesicles. In addition, epigenetic changes such as DNA methylation, histone acetylation and abnormal expression of miRNA reduce the first-phase insulin secretion by affecting the expression of insulin exocytotic proteins.

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备注/Memo

备注/Memo:
通信作者:郗光霞,Email:bettyxgx2018@126.com
更新日期/Last Update: 2021-05-20