参考文献/References:
[1] Pigeyre M,Yazdi FT,Kaur Y,et al.Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity[J].Clin Sci(Lond),2016,130(12):943-986.DOI:10.1042/CS20160136.
[2] van Dijk SJ,Molloy PL,Varinli H,et al.Epigenetics and human obesity[J].Int J Obes(Lond),2015,39(1):85-97.DOI:10.1038/ijo.2014.34.
[3] Shilatifard A. Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression[J].Annu Rev Biochem,2006,75:243-269.DOI:10.1146/annurev.biochem.75.103004.142422.
[4] Lee J,Saha PK,Yang QH,et al.Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis[J].Proc Natl Acad Sci U S A,2008,105(49):19229-19234.DOI:10.1073/pnas.0810100105.
[5] Lee JE,Wang C,Xu S,et al.H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation[J].Elife,2013,2:e01503.DOI:10.7554/eLife.01503.
[6] Shinkai Y,Tachibana M.H3K9 methyltransferase G9a and the related molecule GLP[J].Genes Dev,2011,25(8):781-788.DOI:10.1101/gad.2027411.
[7] Wang L,Xu S,Lee JE,et al.Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis[J].EMBO J,2013,32(1):45-59.DOI:10.1038/emboj.2012.306.
[8] Li SF,Guo L,Qian SW,et al.G9a is transactivated by C/EBPβ to facilitate mitotic clonal expansion during 3T3-L1 preadipocyte differentiation[J].Am J Physiol Endocrinol Metab,2013,304(9):E990-E998.DOI:10.1152/ajpendo.00608.2012.
[9] Ohno H,Shinoda K,Ohyama K,et al.EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex[J].Nature,2013,504(7478):163-167.DOI:10.1038/nature12652.
[10] Nagano G,Ohno H,Oki K,et al.Activation of classical brown adipocytes in the adult human perirenal depot is highly correlated with PRDM16-EHMT1 complex expression[J].PLoS One,2015,10(3):e0122584.DOI:10.1371/journal.pone.0122584.
[11] Wang L,Jin Q,Lee JE,et al.Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis[J].Proc Natl Acad Sci U S A,2010,107(16):7317-7322. DOI:10.1073/pnas.1000031107.
[12] LeBlanc SE,Konda S,Wu Q,et al.Protein arginine methyltransferase 5(Prmt5)promotes gene expression of peroxisome proliferator-activated receptor γ2(PPARγ2)and its target genes during adipogenesis[J].Mol Endocrinol,2012,26(4):583-597.DOI:10.1210/me.2011-1162.
[13] Hu YJ,Sif S,Imbalzano AN.Prmt7 is dispensable in tissue culture models for adipogenic differentiation[J].F1000Res,2013,2:279. DOI:10.12688/f1000research.2-279.v1.
[14] Musri MM,Carmona MC,Hanzu FA,et al.Histone demethylase LSD1 regulates adipogenesis[J].J Biol Chem,2010,285(39):30034-30041.DOI:10.1074/jbc.M110.151209.
[15] Xiong Y,Wang E,Huang Y,et al.Inhibition of lysine-specific demethylase-1(LSD1/KDM1A)promotes the adipogenic differentiation of hESCs through H3K4 methylation[J].Stem Cell Rev,2016,12(3):298-304.DOI:10.1007/s12015-016-9650-z.
[16] Zha L,Li F,Wu R,et al.The histone demethylase UTX promotes brown adipocyte thermogenic program via coordinated regulation of H3K27 demethylation and acetylation[J].J Biol Chem,2015,290(41):25151-25163.DOI:10.1074/jbc.M115.662650.
[17] Ota K,Tong KI,Goto K,et al.The H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stage-dependent manner[J].PLoS One,2017,12(3):e0173713.DOI:10.1371/journal.pone.0173713.
[18] Labbé RM,Holowatyj A,Yang ZQ.Histone lysine demethylase(KDM)subfamily 4: structures, functions and therapeutic potential[J].Am J Transl Res,2013,6(1):1-15.
[19] Whetstine JR,Nottke A,Lan F,et al.Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases[J].Cell,2006,125(3):467-481.DOI:10.1016/j.cell.2006.03.028.
[20] Jang MK,Kim JH,Jung MH.Histone H3K9 demethylase JMJD2B activates adipogenesis by regulating H3K9 methylation on PPARγ and C/EBPα during adipogenesis[J].PLoS One,2017,12(1):e0168185.DOI:10.1371/journal.pone.0168185.
[21] Buerger F,Müller S,Ney N,et al.Depletion of Jmjd1c impairs adipogenesis in murine 3T3-L1 cells[J].Biochim Biophys Acta Mol Basis Dis,2017,1863(7):1709-1717. DOI:10.1016/j.bbadis.2017.05.011.
[22] Tateishi K,Okada Y,Kallin EM,et al.Role of Jhdm2a in regulating metabolic gene expression and obesity resistance[J].Nature,2009,458(7239):757-761.DOI:10.1038/nature07777.
[23] Christensen J,Agger K,Cloos PA,et al.RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3[J].Cell,2007,128(6):1063-1076.DOI:10.1016/j.cell.2007.02.003.
[24] Brier AB,Loft A,Madsen JGS,et al.The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation[J].Nucleic Acids Res,2017,45(4):1743-1759.DOI:10.1093/nar/gkw1156.