[1]张小改 徐书杭 陈国芳 刘超.轻度亚临床甲状腺功能减退症是否需要干预: 基于循证医学的思考[J].国际内分泌代谢杂志,2018,38(06):386-389393.[doi:10.3760/cma.j.issn.1673-4157.2018.06.006]
 Zhang Xiaogai,Xu Shuhang,Chen Guofang,et al.Is interventional therapy in mild subclinical hypothyroidism necessary: thoughts based on evidence[J].International Journal of Endocrinology and Metabolism,2018,38(06):386-389393.[doi:10.3760/cma.j.issn.1673-4157.2018.06.006]
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轻度亚临床甲状腺功能减退症是否需要干预: 基于循证医学的思考()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年06期
页码:
386-389393
栏目:
综述
出版日期:
2018-11-20

文章信息/Info

Title:
Is interventional therapy in mild subclinical hypothyroidism necessary: thoughts based on evidence
作者:
张小改 徐书杭 陈国芳 刘超
作者单位:210028 南京中医药大学附属中西医结合医院(江苏省中医药研究院)内分泌科
Author(s):
Zhang Xiaogai Xu Shuhang Chen Guofang Liu Chao
Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China
关键词:
亚临床甲状腺功能减退症 左甲状腺素 替代治疗
Keywords:
Subclinical hypothyroidism Levothyroxine Replacement therapy
DOI:
10.3760/cma.j.issn.1673-4157.2018.06.006
摘要:
亚临床甲状腺功能减退症(SCH)是较为常见的临床疾病,女性发病率大于男性,并随着年龄和促甲状腺激素水平的升高进一步增加。既往的研究发现,即使轻度SCH亦会增加心血管疾病、代谢性疾病和不良妊娠结局等的风险,并且替代治疗可使整体健康获益。但轻度SCH与骨骼肌系统、认知功能异常、情绪障碍、血脂紊乱和糖尿病等之间的联系及其治疗的临床获益仍存在争议。
Abstract:
Subclinical hypothyroidism(SCH)is a common problem(prevalence is greater in women than men), which increases further with increasing age and thyroid stimulating hormone level. Previous studies suggested that even though mild-SCH had a detrimental effect on cardiovascular risk factors and metabolic diseases, and increased risk of adverse pregnancy outcomes, and that its effective treatment might have a beneficial impact on overall health. However, evidence on the association of mild-SCH and musculoskeletal system, cognitive dysfunction, mood disorders, dyslipidaemia, and diabetes, and the clinical benefits of treatment are controversial.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81200577); 江苏省“六大人才高峰”项目(2013-WSN-063); 江苏省临床医学科技专项-重点病种的规范化诊疗(BL2013040)
Fund program:National Natural Science Foundation of China(81200577); "Six Talents Peak" Project of Jiangsu Province(2013-WSN-063); Specialized Diagnosis and Treat
更新日期/Last Update: 2018-12-30