[1]张莹宵 谭建宇 程庆丰.原发性醛固酮增多症分型方法研究进展[J].国际内分泌代谢杂志,2018,38(05):325-328.[doi:10.3760/cma.j.issn.1673-4157.2018.05.010]
　Zhang Yingxiao,Tan Jianyu,Cheng Qingfeng.Progress of the method in the subtype diagnosis of primary aldosteronism[J].International Journal of Endocrinology and Metabolism,2018,38(05):325-328.[doi:10.3760/cma.j.issn.1673-4157.2018.05.010]
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原发性醛固酮增多症分型方法研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年05期
页码:
325-328
栏目:
临床研究
出版日期:
2018-09-20

文章信息/Info

Title:
Progress of the method in the subtype diagnosis of primary aldosteronism
作者:
张莹宵 谭建宇 程庆丰
作者单位:400010 重庆医科大学附属第一医院内分泌科
Author(s):
Zhang Yingxiao;  Tan Jianyu;  Cheng Qingfeng
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
关键词:
原发性醛固酮增多症;  肾上腺静脉取血;  分泌醛固酮的肾上腺皮质腺瘤;  双侧肾上腺增生
Keywords:
Primary aldosteronism;  Adrenal venous sampling;  Aldosterone producing adrenocortical adenoma;  Bilateral adrenal hyperplasia
DOI:
10.3760/cma.j.issn.1673-4157.2018.05.010
摘要:
肾上腺静脉取血术(AVS)是原发性醛固酮增多症(原醛症)分型诊断的金标准,但存在费用贵,技术难度高,不易推广的缺点。所以寻求AVS替代方法是临床的热点。有学者在CT、MR、131I-6β-甲基碘化胆固醇肾上腺扫描(NP-59)和PET-CT上进行了尝试,也试图通过试验指标和临床模型来预测原醛症亚型。遗憾的是,没有明确的证据表明这些无创方法可以替代AVS,但这些方法能为无法开展AVS的单位提供借鉴。
Abstract:
Adrenal venous sampling(AVS)is the gold-standard etiological diagnostic test in primary aldosteronism, however, it is costly, difficult and hard to popularize. Searching for the alternative of AVS is hot in clinic. Some scholars try to replace AVS with CT, MR, 131I-6β- methyliodized cholesterol adrenal scan(NP-59)and PET-CT, or try to predict the subtype of primary aldosteronism by test indices and clinical models. Unfortunately, there is no obvious evidence that these noninvasive methods can replace AVS, but they can be references to the unit which can not carry out AVS.

参考文献/References:


[1] Funder JW,Carey RM,Mantero F,et al.The management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine society clinical practice guideline[J].J Clin Endocrinol Metab,2016,101(5):1889-1916.DOI:10.1210/jc.2015-4061.
[2] Galati SJ,Hopkins SM,Cheesman KC,et al.Primary aldosteronism: emerging trends[J].Trends Endocrinol Metab,2013,24(9):421-430.DOI:10.1016/j.tem.2013.05.003.
[3] Mulatero P,Bertello C,Rossato D,et al.Roles of clinical criteria, computed tomography scan, and adrenal vein sampling in differentialdiagnosis of primary aldosteronism subtypes[J].J Clin Endocrinol Metab,2008,93(4):1366-1371.DOI:10.1210/jc.2007-2055.
[4] Young WF,Stanson AW,Thompson GB,et al.Role for adrenal venous sampling in primary aldosteronism[J].Surgery,2004,136(6):1227-1235.DOI:10.1016/j.surg.2004.06.051.
[5] Nwariaku FE,Miller BS,Auchus R,et al.Primary hyperaldosteronism: effect of adrenal vein sampling on surgical outcome[J].Arch Surg,2006,141(5):497-502; discussion 502-503.DOI:10.1001/archsurg.141.5.497.
[6] Kempers MJ,Lenders JW,van Outheusden L,et al.Systematic review: diagnostic procedures to differentiate unilateral from bilateral adrenal abnormality in primary aldosteronism[J].Ann Intern Med,2009,151(5):329-337.
[7] Dekkers T,Prejbisz A,Kool LJS,et al.Adrenal vein sampling versus CT scan to determine treatment in primary aldosteronism: an outcome-based randomised diagnostic trial[J].Lancet Diabetes Endocrinol,2016,4(9):739-746.DOI:10.1016/S2213-8587(16)30100-0.
[8] Puar TH,Khoo JJ,Ng KS,et al.Adrenal vein sampling versus CT scanning in primary aldosteronism[J].Lancet Diabetes Endocrinol,2016,4(11):885-886.DOI:10.1016/S2213-8587(16)30235-2.
[9] Rossi GP,Funder JW.Adrenal venous sampling versus computed tomographic scan to determine treatment in primary aldosteronism(The SPARTACUS Trial): a critique[J].Hypertension,2017,69(3):396-397.DOI:10.1161/HYPERTENSIONAHA.116.08820.
[10] Sukor N,Gordon RD,Ku YK,et al.Role of unilateral adrenal ectomy in bilateral primary aldosteronism: a 22-year single center experience[J].J Clin Endocrinol Metab,2009,94(7):2437-2445.DOI:10.1210/jc.2008-2803.
[11] Burton TJ,Mackenzie IS,Balan K,et al.Evaluation of the sensitivity and specificity of(11)C-metomidate positron emission tomography(PET)-CT for lateralizing aldosterone secretion by Conn's adenomas[J].J Clin Endocrinol Metab,2012,97(1):100-109.DOI:10.1210/jc.2011-1537.
[12] Hennings J,Sundin A,Hägg A,et al.11C-metomidate positron emission tomography after dexamethasone suppression for detection of small adrenocortical adenomas in primary aldosteronism[J].Langenbecks Arch Surg,2010,395(7):963-967.DOI:10.1007/s00423-010-0681-7.
[13] Abe T,Naruse M,Young WF Jr,et al.A novel CYP11B2-specific imaging agent for detection of unilateral subtypes of primary aldosteronism[J].J Clin Endocrinol Metab,2016,101(3):1008-1015.DOI:10.1210/jc.2015-3431.
[14] Riester A,Fischer E,Degenhart C,et al.Age below 40 or a recently proposed clinical prediction score cannot bypass adrenal venous sampling in primary aldosteronism[J].J Clin Endocrinol Metab,2014,99(6):E1035-E1039.DOI:10.1210/jc.2013-3789.
[15] Lim V,Guo Q,Grant CS,et al.Accuracy of adrenal imaging and adrenal venous sampling in predicting surgical cure of primary aldosteronism[J].J Clin Endocrinol Metab,2014,99(8):2712-2719.DOI:10.1210/jc.2013-4146.
[16] Küpers EM,Amar L,Raynaud A,et al.A clinical prediction score to diagnose unilateral primary aldosteronism[J].J Clin Endocrinol Metab,2012,97(10):3530-3537. DOI:10.1210/jc.2012-1917.
[17] Sze WC,Soh LM,Lau JH,et al.Diagnosing unilateral primary aldosteronism - comparison of a clinical prediction score, computed tomography and adrenal venous sampling[J].Clin Endocrinol(Oxf),2014,81(1):25-30.DOI:10.1111/cen.12374.
[18] Zhang Y,Niu W,Zheng F,et al.Identifying unilateral disease in Chinese patients with primary aldosteronism by using a modified prediction score[J].J Hypertens,2017,35(12):2486-2492.DOI:10.1097/HJH.0000000000001488.
[19] Sonoyama T,Sone M,Miyashita K,et al.Significance of adrenocorticotropin stimulation test in the diagnosis of an aldosterone-producing adenoma[J].J Clin Endocrinol Metab,2011,96(9):2771-2778.DOI:10.1210/jc.2011-0573.
[20] Moriya A,Yamamoto M,Kobayashi S,et al.ACTH stimulation test and computed tomography are useful for differentiating the subtype of primary aldosteronism[J].Endocr J,2017,64(1):65-73.DOI:10.1507/endocrj.EJ16-0297.
[21] Mulatero P,di Cella SM,Monticone S,et al.18-hydroxycorticosterone, 18-hydroxycortisol, and 18-oxocortisol in the diagnosis of primary aldosteronism and its subtypes[J].J Clin Endocrinol Metab,2012,97(3):881-889.DOI:10.1210/jc.2011-2384.
[22] Satoh F,Morimoto R,Ono Y,et al.Measurement of peripheral plasma 18-oxocortisol can discriminate unilateral adenoma from bilateral diseases in patients with primary aldosteronism[J].Hypertension,2015,65(5):1096-1102.DOI:10.1161/HYPERTENSIONAHA.114.04453.
[23] Mulatero P,Stowasser M,Loh KC,et al.Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents[J].J Clin Endocrinol Metab,2004,89(3):1045-1050.DOI:10.1210/jc.2003-031337.
[24] Phillips JL,Walther MM,Pezzullo JC,et al.Predictive value of preoperative tests in discriminating bilateral adrenal hyperplasia from an aldosterone-producing adrenal adenoma[J].J Clin Endocrinol Metab,2000,85(12):4526-4533.DOI:10.1210/jcem.85.12.7086.

备注/Memo

备注/Memo:
基金项目:重庆市科委面上项目(cstc2015jcyjA10092)
Fund program:The General Program of Science and Technology Commisson of Chongqing(cstc2015jcyjA10092)
作者单位:400010 重庆医科大学附属第一医院内分泌科
通信作者:程庆丰,Email:cqf19760516@163.com
更新日期/Last Update: 2018-09-30