[1]黄慧 胡欣 徐一娇 刘超.利妥昔单克隆抗体治疗Graves病的作用机制[J].国际内分泌代谢杂志,2018,38(02):121-123.[doi:10.3760/cma.j.issn.1673-4157.2018.02.013]
 Huang Hui,Hu Xin,Xu Yijiao,et al.Mechanism of rituximab in the treatment of Graves' disease[J].International Journal of Endocrinology and Metabolism,2018,38(02):121-123.[doi:10.3760/cma.j.issn.1673-4157.2018.02.013]
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利妥昔单克隆抗体治疗Graves病的作用机制()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年02期
页码:
121-123
栏目:
临床研究
出版日期:
2018-03-20

文章信息/Info

Title:
Mechanism of rituximab in the treatment of Graves' disease
作者:
黄慧 胡欣 徐一娇 刘超
210028 南京中医药大学附属中西医结合医院内分泌代谢病院区; 江苏省中医药研究院
Author(s):
Huang Hui Hu Xin Xu Yijiao Liu Chao
Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Jiangsu Branch of China Academy of Chinese Medical Science, Nanjing 210028, China
关键词:
利妥昔单克隆抗体 Graves病 B淋巴细胞
Keywords:
Rituximab Graves' disease B lymphocyte
DOI:
10.3760/cma.j.issn.1673-4157.2018.02.013
摘要:
Graves病(GD)是一种B淋巴细胞介导、T淋巴细胞依赖的器官特异性自身免疫性疾病。利妥昔单克隆抗体(RTX)是一种人鼠嵌合型抗CD20单克隆抗体,与B淋巴细胞膜上CD20抗原特异性结合,通过补体依赖性细胞毒作用、抗体依赖性细胞毒作用、以及直接诱导细胞凋亡来杀伤B淋巴细胞。RTX在改善GD患者甲状腺功能、降低GD复发率及甲状腺相关抗体滴度方面卓有成效。
Abstract:
Graves' disease is a B lymphocyte-mediated and T lymphocyte-dependent organ specific autoimmune disease. Rituximab(RTX), the human/mouse chimeric anti-CD20 monoclonal antibody, combines with CD20 antigen of B lymphocytes' surface specifically and kills B lymphocyte through complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity and induction of direct cell death. RTX can markedly improve the thyroid function, decrease the recurrence rate and the antibody levels related to thyroid of patients with Graves' disease.

参考文献/References:


[1] Okosieme OE,Lazarus JH.Current trends in antithyroid drug treatment of Graves' disease[J].Expert Opin Pharmacother,2016,17(15):2005-2017.DOI:10.1080/14656566.2016.1232388.
[2] Abulayha A,Bredan A,El Enshasy H,et al.Rituximab: modes of action, remaining dispute and future perspective[J].Future Oncol,2014,10(15):2481-2492.DOI:10.2217/fon.14.146.
[3] Ueki I,Abiru N,Kobayashi M,et al.B cell-targeted therapy with anti-CD20 monoclonal antibody in a mouse model of Graves' hyperthyroidism[J].Clin Exp Immunol,2011,163(3):309-317.DOI:10.1111/j.1365-2249.2010.04301.x.
[4] Braley-Mullen H,Yu S.Early requirement for B cells for development of spontaneous autoimmune thyroiditis in NOD.H-2h4 mice[J].J Immunol,2000,165(12):7262-7269.
[5] Pichurin P,Aliesky H,Chen CR,et al.Thyrotrophin receptor-specific memory T cell responses require normal B cells in a murine model of Graves' disease[J].Clin Exp Immunol,2003,134(3):396-402.
[6] Rudnicki M.Rituximab for treatment of membranoproliferative glomerulonephritis and C3 glomerulopathies[J].Biomed Res Int,2017,2017:2180508.DOI:10.1155/2017/2180508.
[7] Lenz G,Dreyling M,Hoster E,et al.Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-term outcome in patients with previously untreated mantle cell lymphoma: results of a prospective randomized trial of the German Low Grade Lymphoma Study Group(GLSG)[J].J Clin Oncol,2005,23(9):1984-1992. DOI:10.1200/JCO.2005.08.133.
[8] Vannucchi G,Campi I,Bonomi M,et al.Rituximab treatment in patients with active Graves' orbitopathy: effects on proinflammatory and humoral immune reactions[J].Clin Exp Immunol,2010,161(3):436-443.DOI:10.1111/j.1365-2249.2010.04191.x.
[9] El Fassi D,Nielsen CH,Bonnema SJ,et al.B lymphocyte depletion with the monoclonal antibody rituximab in Graves' disease: a controlled pilot study[J].J Clin Endocrinol Metab,2007,92(5):1769-1772.DOI:10.1210/jc.2006-2388.
[10] Heemstra KA,Toes RE,Sepers J,et al.Rituximab in relapsing Graves' disease, a phase Ⅱ study[J].Eur J Endocrinol,2008,159(5):609-615.DOI:10.1530/EJE-08-0084.
[11] El Fassi D,Banga JP,Gilbert JA,et al.Treatment of Graves' disease with rituximab specifically reduces the production of thyroid stimulating autoantibodies[J].Clin Immunol,2009,130(3):252-258.DOI: 10.1016/j.clim.2008.09.007.
[12] Salvi M,Vannucchi G,Campi I,et al.Treatment of Graves' disease and associated ophthalmopathy with the anti-CD20 monoclonal antibody rituximab: an open study[J].Eur J Endocrinol,2007,156(1):33-40. DOI:10.1530/eje.1.02325.
[13] Liu X,Guo H,Liu J,et al.Clinical efficacy of combined rituximab treatment in a woman with severe Graves' ophthalmopathy[J].Exp Ther Med,2016,12(2):1093-1096.DOI:10.3892/etm.2016.3367.
[14] Vallerskog T,Gunnarsson I,Widhe M,et al.Treatment with rituximab affects both the cellular and the humoral arm of the immune system in patients with SLE[J].Clin Immunol,2007,122(1):62-74.DOI:10.1016/j.clim.2006.08.016.
[15] Stasi R,Stipa E,Del Poeta G,et al.Long-term observation of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis treated with rituximab[J].Rheumatology(Oxford),2006,45(11):1432-1436.DOI:10.1093/rheumatology/kel098.
[16] 冯凯旋,任丽君,夏振娜,等.抗CD20单克隆抗体研究进展[J].中外健康文摘,2013,10(25):123-124.
[17] 陈净,李剑.利妥昔单抗的罕见不良反应[J].药物不良反应杂志,2010,12(5):321-323.DOI:10.3969/j.issn.1008-5734.2010.05.005.
[18] El Fassi D,Nielsen CH,Junker P,et al.Systemic adverse events following rituximab therapy in patients with Graves' disease[J].J Endocrinol Invest,2011,34(7):e163-e167.DOI:10.3275/7411.

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备注/Memo

备注/Memo:
基金项目:江苏省科技计划项目(BK20141037)
通信作者:刘超,Email: liuchao@nfmcn.com
更新日期/Last Update: 1900-01-01