[1]冬梅,金淑霞,韩杏梅.应力负荷与骨骼结构及骨重建的关系[J].国际内分泌代谢杂志,2017,37(05):321-323.
　Dong Mei,Jin Shuxia,Han Xingmei..Effects of mechanical loading on bone structure and bone remodeling[J].International Journal of Endocrinology and Metabolism,2017,37(05):321-323.
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应力负荷与骨骼结构及骨重建的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年05期
页码:
321-323
栏目:
综述
出版日期:
2017-09-20

文章信息/Info

Title:
Effects of mechanical loading on bone structure and bone remodeling
作者:
冬梅; 金淑霞; 韩杏梅
010030 呼和浩特,内蒙古医科大学第二附属医院骨内科
Author(s):
Dong Mei;  Jin Shuxia;  Han Xingmei.
Department of Orthopedic Medicine, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China
关键词:
骨重建;  应力负荷;  骨细胞
Keywords:
Bone remodeling;  Mechanical loading;  Osteocyte
文献标志码:
A
摘要:
应力负荷是骨质量和骨骼几何形状的主要调节因子。骨细胞信号网络通过感知骨骼力学负荷而发挥作用,是应力负荷的主要传感器。骨细胞死亡后发生骨重建,骨骼力学负荷减小或丧失。骨折后所致长期卧床、局部制动导致骨细胞凋亡和骨吸收,引起严重的骨质疏松。通过分析骨骼适应应力负荷的机制,骨细胞感受机械刺激和骨骼的力学负荷,力学负荷对骨骼的作用和应力负荷与骨重塑过程的分子调控等,可以探讨应力负荷与骨骼结构及与骨重建的关系。
Abstract:
Mechanical loading is a major regulator of bone mass and bone geometry. The osteocytes signal network plays an important role through the mechanical load, which is considered the main sensor of loads. Bone remodeling occurs after osteocyte dies, thereby the skeletal mechanical load reduces or loses. Long-term bed rest and inactive mode caused by fracture, lead to osteocyte apoptosis and bone resorption, therefore leading to severe osteoporosis. By analyzing the mechanism of mechanical adaptation of bone, the mechanical stimulation of osteocyte and the mechanical load of bone, the relationship of mechanical load and bone structure, bone remodeling process can be investigated.

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备注/Memo

备注/Memo:
基金项目:内蒙古自治区高等学校科学研究项目(NJSY16102); 内蒙古医科大学第二附属医院基金项目(2015YJJS016); 内蒙古自治区留学人员科技活动项目择优资助项目(2015025)
通信作者:冬梅, Email:namiraa@gmail.com
更新日期/Last Update: 2017-09-30