[1]项芬芬,张学梅,高英慧,等.p53与物质能量代谢的关系[J].国际内分泌代谢杂志,2017,37(04):262-265.
　Xiang Fenfen*,Zhang Xuemei,Gao Yinghui,et al.Relationship between p53 and material, energy metabolism[J].International Journal of Endocrinology and Metabolism,2017,37(04):262-265.
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p53与物质能量代谢的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年04期
页码:
262-265
栏目:
综述
出版日期:
2017-07-20

文章信息/Info

Title:
Relationship between p53 and material, energy metabolism
作者:
项芬芬; 张学梅; 高英慧; 冯一丹; 段薇
116001 大连大学附属中山医院内分泌科(项芬芬,高英慧,冯一丹,段薇); 116622 大连大学医学院(张学梅)
Author(s):
Xiang Fenfen*;  Zhang Xuemei;  Gao Yinghui;  Feng Yidan;  Duan Wei.
*Department of Endocrinology, The Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China
关键词:
p53;  葡萄糖代谢;  脂代谢;  能量代谢;  代谢性疾病
Keywords:
p53;  Glucose metabolism;  Lipid metabolism;  Energy metabolism;  Metabolic diseases
文献标志码:
A
摘要:
p53是肿瘤抑制基因,也是参与调节各种反应的转录因子,其表达的蛋白是一种能够激活或者抑制下游基因转录的核蛋白。由于细胞种类、应激状态、所处环境以及细胞内p53表达状态的不同,p53通过多种不同的细胞通路来参与调节糖代谢、脂代谢、能量代谢,甚至与代谢性疾病的发生有一定的关系。
Abstract:
p53 is not only a tumor suppressor but also a transcription factor which involved in regulating different kinds of reaction. The expression of p53 is a kind of nucleoprotein which can activate or inhibit a variety of down-stream gene's transcription. Because of different kinds, states, environment of cells, and the state of p53 expression in cells, p53 participates in a variety of cellular pathways to regulate glucose metabolism, lipid metabolism, energy metabolism, even metabolic disease.

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备注/Memo

备注/Memo:
基金项目:“十二五”国家科技支撑计划项目(2012BAK25B00)
通信作者:段薇,Email: duanwei34@hotmail.com
更新日期/Last Update: 2017-07-30