[1]张仁龙,杨玉.婴幼儿单纯乳房早发育的病因研究进展[J].国际内分泌代谢杂志,2017,37(02):139-142.[doi:10.3760/cma.j.issn.1673-4157.2017.02.018]
　Zhang Renlong,Yang Yu..The progress of isolated premature thelarche pathogeny in infants and toddlers[J].International Journal of Endocrinology and Metabolism,2017,37(02):139-142.[doi:10.3760/cma.j.issn.1673-4157.2017.02.018]
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婴幼儿单纯乳房早发育的病因研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年02期
页码:
139-142
栏目:
综述
出版日期:
2017-03-20

文章信息/Info

Title:
The progress of isolated premature thelarche pathogeny in infants and toddlers
作者:
张仁龙; 杨玉
330006 南昌,江西省儿童医院内分泌遗传代谢科
Author(s):
Zhang Renlong;  Yang Yu.
Department of Endocrine Genetics and Metabolism, Children’s Hospital of Jiangxi Province, Nanchang 330006, China
关键词:
单纯乳房早发育;  婴幼儿;  性早熟;  内分泌干扰物;  小青春期
Keywords:
Isolated premature thelarche;  Infants and toddlers;  Precocious puberty;  Endocrine disrupting chemicals;  Mini-puberty
DOI:
10.3760/cma.j.issn.1673-4157.2017.02.018
摘要:
据相关流行病学资料,单纯乳房早发育在婴幼儿并不少见; 部分患儿的单纯乳房早发育会发展为中枢性性早熟,导致其成年终身高受损,并给其心理健康留下隐患。因此明确婴幼儿单纯乳房早发育的病因对其治疗非常重要。除了生理性小青春期、疾病(卵巢囊肿)及遗传因素外,它的病因还包括误服某些药物、生活环境和营养因素。其中前者是内因,或机体自身分泌雌激素增多,或乳房的雌激素受体对雌激素敏感性增加; 后者为外因,或食道摄入雌激素或类雌激素增多,或环境影响(光照、迁徙、环境内分泌干扰物)。
Abstract:
Isolated premature thelarche(IPT)in infants and toddlers are not uncommon, according to the relevant epidemiological data; there is a possibility that IPT may deteriotare into central precocious puberty,causing the lower final height in their adulthood and probably making a negative impact on their mental health while growing old. Therefore,to make clear the pathogeny of IPT in infants and toddlers is critical to treatment.In addition to the physiological "mini-puberty", disease(ovarian cyst)and genetic factor, IPT also results from some drugs, living environment and nutrition.Among which,the former are endopathic factors that either organism secrete too much oestrogen or oestrogen receptors of breast tissue become more sensitive to oestrogen; the latter are exopathic factors that either much more oestrogen or oestrogen-like substance is taken or environmental influence(lighting,migration,endocrine disrupting chemicals).

参考文献/References:

[1] Neely EK, Crossen SS. Precocious puberty[J].Curr Opin Obstet Gynecol,2014,26(5):332-338. DOI: 10.1097/GCO.0000000000000099.
[2] 王卫平,沈晓明. 儿科学[M]. 第7版. 北京:人民卫生出版社, 2011: 427.
[3] 顔纯,王慕逖. 小儿内分泌学[M]. 第二版. 北京: 人民卫生出版社, 2006: 307-308.
[4] 倪继红,王德芬,王伟,等. 上海地区2～13岁女童乳房发育调查[J]. 中华内分泌代谢杂志, 2002, 18(4): 297-299.DOI:10.3760/j.issn:1000-6699.2002.04.017.
[5] Atay Z, Turan S, Guran T, et al. The prevalence and risk factors of premature thelarche and pubarche in 4- to 8-year-old girls[J].Acta Paediatr,2012,101(2):e71-e75. DOI: 10.1111/j.1651-2227.2011.02444.x.
[6] 郭友宁,吴敏伦,沈水仙. 上海市5岁内女童乳房早发育患病率及影响因素的分析[J]. 实用儿科临床杂志, 2002,17(1): 49-52.DOI:10.3969/j.issn.1003-515X.2002.01.024.
[7] Larriuz-Serrano MC, Pérez-Cardona CM, Ramos-Valencia G,et al. Natural history and incidence of premature thelarche in Puerto Rican girls aged 6 months to 8 years diagnosed between 1990 and 1995[J].P R Health Sci J,2001,20(1):13-18.
[8] 王燕,王爱萍,孔莉芳,等.婴幼儿乳房发育的全国多中心研究初探. 中华儿科杂志,2014,52(1):5-10.DOI:10.3760/cma.j.jssn.0578-1310.2014.01.003.
[9] Curfman AL, Reljanovic SM, McNelis KM, et al. Premature thelarche in infants and toddlers: prevalence, natural history and environmental determinants[J].J Pediatr Adolesc Gynecol,2011,24(6):338-341.DOI:10.1016/j.jpag.2011.01.003.
[10] 刘莉,郑峥. 37例乳房早发育婴幼儿与正常婴幼儿发育商的对比研究[J]. 军事医学, 2013,37(9): 706-707. DOI:10.7644/j.issn.1674-9960.2013.09.017.
[11] Ojeda SR, Ma YJ. Glial-neuronal interactions in the neuroendocrine control of mammalian puberty: facilitatory effects of gonadal steroids[J].J Neurobiol,1999,40(4):528-540.
[12] 石乔,杨玉. 0-2岁婴幼儿乳房早发育的临床随访研究[J]. 国际内分泌代谢杂志,2015, 35(5): 309-313.DOI:10.3760/cma.j.issn.1673-4157.2015.05.006.
[13] Kaplowitz PB, Mehra R. Clinical characteristics of children referred for signs of early puberty before age 3[J].J Pediatr Endocrinol Metab,2015,28(9-10):1139-1144. DOI: 10.1515/jpem-2015-0124.
[14] 王应旻,梁黎,方燕兰,等.小于2岁婴幼儿乳房早发育临床随访研究[J].中国当代儿科杂志,2013,15(4):285-288.DOI: 10.7499/j.issn.1008-8830.2013.04.010.
[15] Zhu SY, Du ML, Huang TT. An analysis of predictive factors for the conversion from premature thelarche into complete central precocious puberty[J].J Pediatr Endocrinol Metab,2008,21(6):533-538.DOI:10.3969/j.issn.1005-2224.2008.03.007.
[16] U?r A, Saka N, Ba F,et al. Is premature thelarche in the first two years of life transient?[J].J Clin Res Pediatr Endocrinol,2012,4(3):140-145.DOI:10.4274/Jcrpe.709.
[17] 卫海燕,付东霞,方莉辉. 婴幼儿乳房早发育病因探讨和随访研究[J]. 中国儿童保健杂志, 2014, 22(8): 853-855.DOI:10.11852/zgetbjzz2014-22-08-22.
[18] Kronenberg HM,Melmed S,Polonsky KS,et al. Williams Textbook of Endocrinology [M]. Eleventh Edition. Beijing: People’s Military Medical Press, 2011: 1023.
[19] Kronenberg HM,Melmed S,Polonsky KS,et al. Williams Textbook of Endocrinology [M]. Eleventh Edition. Beijing: People’s Military Medical Press, 2011: 1034.
[20] 杨玉,王荻兰. 207例0～2岁女童单纯乳房早发育相关危险因素分析[J]. 中国儿童保健杂志, 2014, 22(2): 190-193.
[21] Luan X, Yu H, Wei X, et al. GPR54 polymorphisms in Chinese girls with central precocious puberty[J].Neuroendocrinology,2007,86(2):77-83. DOI:10.1159/000107511.
[22] Luan X, Zhou Y, Wang W,et al. Association study of the polymorphisms in the KISS1 gene with central precocious puberty in Chinese girls[J].Eur J Endocrinol,2007,157(1):113-118.DOI:10.1530/EJE-07-0061.
[23] 柯江维,杨玉,段荣,等. 雌激素受体α基因多态性与女孩性早熟关系的研究[J]. 中国实验诊断学, 2010,14(10): 1628-1632.DOI:10.3969/j.issn.1007-4287.2010.10.041.
[24] Durmaz E, Turkkahraman D, Berdeli A, et al. A novel DAX-1 mutation presented with precocious puberty and hypogonadotropic hypogonadism in different members of a large pedigree[J].J Pediatr Endocrinol Metab,2013,26(5-6):551-555. DOI: 10.1515/jpem-2012-0086.
[25] Seminara SB. Kisspeptin in reproduction[J].Semin Reprod Med,2007,25(5):337-343.DOI: 10.1055/s-2007-984739.
[26] Gingerich S, Wang X, Lee PK,et al. The generation of an array of clonal, immortalized cell models from the rat hypothalamus: analysis of melatonin effects on kisspeptin and gonadotropin-inhibitory hormone neurons[J].Neuroscience,2009,162(4):1134-1140. DOI: 10.1016/j.neuroscience.2009.05.026.
[27] Mitre N, Lteif A. Treatment of familial male-limited precocious puberty(testotoxicosis)with anastrozole and bicalutamide in a boy with a novel mutation in the luteinizing hormone receptor[J].J Pediatr Endocrinol Metab,2009,22(12):1163-1167.
[28] Vinogradova IA, Iliukha VA, Khizhkin EA,et al. Light pollution, desynchronosis and aging: the state of problem and solutions[J].Adv Gerontol,2014,27(2):265-268.
[29] Teilmann G, Pedersen CB, Skakkebaek NE, et al. Increased risk of precocious puberty in internationally adopted children in Denmark[J].Pediatrics,2006,118(2):e391-e399.DOI: 10.1542/peds.2005-2939.
[30] 武翔靓. 2岁以下女婴单纯性乳房早发育临床研究与危险因素调查[D]. 首都医科大学,2014.
[31] Colón I, Caro D, Bourdony CJ, et al. Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development[J].Environ Health Perspect,2000,108(9):895-900.
[32] Lee HR, Jeung EB, Cho MH,et al. Molecular mechanism(s)of endocrine-disrupting chemicals and their potent oestrogenicity in diverse cells and tissues that express oestrogen receptors[J].J Cell Mol Med,2013,17(1):1-11. DOI: 10.1111/j.1582-4934.2012.01649.x.
[33] Sheikh IA, Turki RF, Abuzenadah AM,et al. Endocrine disruption: computational perspectives on human sex hormone-binding globulin and phthalate plasticizers[J].PLoS One,2016,11(3):e0151444. DOI: 10.1371/journal.pone.0151444.
[34] Makita Y, Omura M, Tanaka A, et al. Effects of concurrent exposure to tributyltin and 1,1-dichloro-2,2 bis(p-chlorophenyl)ethylene(p,p’-DDE)on immature male Wistar rats[J].Basic Clin Pharmacol Toxicol,2005,97(6):364-368.DOI: 10.1111/j.1742-7843.2005.pto 199.x.
[35] Bottomley C, Bourne T. Diagnosis and management of ovarian cyst accidents[J].Best Pract Res Clin Obstet Gynaecol,2009,23(5):711-724. DOI: 10.1016/j.bpobgyn.2009.02.001.
[36] 储明星,冯涛,狄冉等, 哺乳动物性早熟相关基因的研究进展[J].遗传, 2009,31(1):13-28. DOI:10.3724/SP.J.1005.2009.00013.

相似文献/References:

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　Yang Yu,Shi Qiao.A clinical follow up study of premature thelarche in 0 to 2-year-old infants[J].International Journal of Endocrinology and Metabolism,2015,(02):309.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.006]
[2]杨玉 张仁龙 熊翔宇 杨利 谢理玲 石乔 黄慧 陈卡 王荻兰.Kisspeptin水平与婴幼儿女童乳房早发育的 相关性研究[J].国际内分泌代谢杂志,2018,38(05):302.[doi:10.3760/cma.j.issn.1673-4157.2018.05.004]
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备注/Memo

备注/Memo:
通信作者:杨玉,Email:yangyu5168@126.com
更新日期/Last Update: 2017-03-20