[1]彭静,刘煜,曹真真.亚临床甲状腺功能减退症对糖尿病血管并发症的影响[J].国际内分泌代谢杂志,2017,37(01):23-26.[doi:10.3760/cma.j.issn.1673-4157.2017.01.07]
 Peng Jing*,Liu Yu,Cao Zhenzhen..Influence of subclinical hypothyroidism on diabetic vascular complications[J].International Journal of Endocrinology and Metabolism,2017,37(01):23-26.[doi:10.3760/cma.j.issn.1673-4157.2017.01.07]
点击复制

亚临床甲状腺功能减退症对糖尿病血管并发症的影响()
分享到:

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年01期
页码:
23-26
栏目:
综述
出版日期:
2017-01-20

文章信息/Info

Title:
Influence of subclinical hypothyroidism on diabetic vascular complications
作者:
彭静刘煜曹真真
130000 长春,吉林大学第二临床医学院(彭静); 130000 长春,吉林大学第二医院内分泌科(刘煜,曹真真)
Author(s):
Peng Jing* Liu Yu Cao Zhenzhen.
*The Second Clinical Medical College of Jilin University, Changchun 130000, China
关键词:
糖尿病 亚临床甲状腺功能减退症 糖尿病血管并发症
Keywords:
Diabetes mellites Subclinical hypothyroidism Diabetic vascular complications
DOI:
10.3760/cma.j.issn.1673-4157.2017.01.07
摘要:
糖尿病和甲状腺功能障碍是常见的内分泌代谢疾病,糖尿病患者中合并甲状腺功能异常者越来越多,其中以亚临床甲状腺功能减退症居多。目前大多数研究认为,亚临床甲状腺功能减退症可通过引起血脂紊乱、血流动力学异常及内皮功能紊乱等机制,参与并加重糖尿病微血管及大血管并发症。
Abstract:
Diabetes and thyroid dysfunction are common endocrine metabolic disease. Abnormal thyroid function in patients with diabetes is increasing, particularly with subclinical hypothyroidism. Recently, most studies show that subclinical hypothyroidism participates in and increases diabetic microvascular and macrovascular complications by inducing dyslipidemia, hemodynamic abnormalities and endothelial dysfunction.

参考文献/References:

[1] Papazafiropoulou A, Sotiropoulos A, Kokolaki A,et al. Prevalence of thyroid dysfunction among Greek type 2 diabetic patients attending an outpatient clinic[J].J Clin Med Res, 2010,2(2):75-78. DOI: 10.4021/jocmr2010.03.281w.
[2] Arya S, Shah B, Arya IN, et al. An elucidatory review of the association between thyroid disorders and diabetes[J]. Int J Med Sci Public Health, 2013,2(4):797-800. DOI:10.5455/ijmsph.2013.010920133.
[3] Chen HS, Wu TE, Jap TS,et al. Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in type 2 diabetic patients[J].Diabet Med,2007,24(12):1336-1344. DOI:10.1111/j.1464-5491.2007.02270.x.
[4] Furukawa S, Yamamoto S, Todo Y, et al. Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus[J].Endocr J,2014,61(10):1011-1018.
[5] 邵芬,李晓行,章臻翊,等.亚临床甲状腺功能减退与2型糖尿病慢性并发症的相关性[J].医学临床研究,2014,31(7):1291-1293. DOI:10.3969/j.issn.1671-7171.2014.07.015.
[6] 徐静,朱凤.亚临床甲状腺功能减退症与2 型糖尿病微血管并发症关系的研究[J].中国实用医药,2015,10(34):100-101.DOI:10.14163/j.cnki.11-5547/r.2015.34.071.
[7] Ramis JN, Artigas CF, Santiago MA,et al. Is there a relationship between TSH levels and diabetic retinopathy in the Caucasian population[J].Diabetes Res Clin Pract,2012,97(3):e45-e47. DOI: 10.1016/j.diabres.2012.05.015.
[8] Yang JK, Liu W, Shi J,et al. An association between subclinical hypothyroidism and sight-threatening diabetic retinopathy in type 2 diabetic patients[J].Diabetes Care,2010,33(5):1018-1020. DOI: 10.2337/dc09-1784.
[9] Yang GR, Yang JK, Zhang L, et al. Association between subclinical hypothyroidism and proliferative diabetic retinopathy in type 2 diabetic patients: a case-control study[J].Tohoku J Exp Med,2010,222(4):303-310.
[10] Kim BY, Kim CH, Jung CH,et al. Association between subclinical hypothyroidism and severe diabetic retinopathy in Korean patients with type 2 diabetes[J].Endocr J,2011,58(12):1065-1070.
[11] Wu J, Yue S, Geng J, et al. Relationship between diabetic retinopathy and subclinical hypothyroidism: a meta-analysis[J].Sci Rep,2015,5:12212. DOI: 10.1038/srep12212.
[12] Schalkwijk CG, Stehouwer CD. Vascular complications in diabetes mellitus: the role of endothelial dysfunction[J].Clin Sci(Lond),2005,109(2):143-159. DOI:10.1042/CS20050025.
[13] 陈晖, 郭媛.2型糖尿病视网膜病变患者检测HCY和血流变学指标的意义[J].海南医学院学报,2012,18(3):325-326.DOI:10.13210/j.cnki.jhmu.2012.03.028.
[14] Sen U, Pushpakumar SB, Amin MA, et al. Homocysteine in renovascular complications: hydrogen sulfide is a modulator and plausible anaerobic ATP generator[J].Nitric Oxide,2014,41:27-37. DOI: 10.1016/j.niox.2014.06.006.
[15] Sieber J, Lindenmeyer MT, Kampe K, et al. Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids[J].Am J Physiol Renal Physiol,2010,299(4):F821-F829. DOI: 10.1152/ajprenal.00196.2010.
[16] Chung JJ, Huber TB, Gödel M, et al. Albumin-associated free fatty acids induce macropinocytosis in podocytes[J].J Clin Invest, 2015,125(6):2307-2316. DOI: 10.1172/JCI79641.
[17] 陈辉雄,张丽萍, 陈玉华.探讨同型半胱氨酸、血脂及血液流变学在糖尿病视网膜病变中的意义[J].检验医学与临床,2014,11(9):1179-1181.DOI:10.3969/j.issn.1672-9455.2014.09.012.
[18] Kvetny J, Heldgaard PE, Bladbjerg EM,et al. Subclinical hypothyroidism is associated with a low-grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50 years[J].Clin Endocrinol(Oxf),2004,61(2):232-238. DOI:10.1111/j.1365-2265.2004.02088.x.
[19] Mahto M, Chakraborthy B, Gowda SH,et al. Are hsCRP levels and LDL/HDL ratio better and early markers to unmask onset of dyslipidemia and inflammation in asymptomatic subclinical hypothyroidism [J].Indian J Clin Biochem,2012,27(3):284-289. DOI: 10.1007/s12291-012-0206-y.
[20] You YK, Huang XR, Chen HY, et al. C-Reactive protein promotes diabetic kidney disease in db/db mice via the CD32b-Smad3-mTOR signaling pathway[J].Sci Rep,2016,6:26740. DOI: 10.1038/srep26740.
[21] Muni RH, Kohly RP, Lee EQ,et al. Prospective study of inflammatory biomarkers and risk of diabetic retinopathy in the diabetes control andcomplications trial[J].JAMA Ophthalmol,2013,131(4):514-521. DOI: 10.1001/jamaophthalmol.2013.2299.
[22] Ceki S, Cvetkovi T, Jovanovi I, et al. C-reactive protein and chitinase 3-like protein 1 as biomarkers of spatial redistribution of retinal blood vessels on digital retinal photography in patients with diabetic retinopathy[J].Bosn J Basic Med Sci,2014,14(3):177-184. DOI: 10.17305/bjbms.2014.3.21.
[23] Gen R, Akbay E, Sezer K. Insulin resistance and cardiovascular risk factors in patients with mild and severe subclinical hypothyroidism[J]. Endocrinologist, 2010, 20(3):128-130.DOI:10.1097/TEN.0b013c3181dfc618.
[24] Forst T, Weber MM, Mitry M, et al. Pilot study for the evaluation of morphological and functional changes in retinal blood flow in patients with insulin resistance and/or type 2 diabetes mellitus[J].J Diabetes Sci Technol,2012,6(1):163-168.
[25] Singer MA. Of mice and men and elephants: metabolic rate sets glomerular filtration rate[J].Am J Kidney Dis,2001,37(1):164-178.
[26] 刘光政.有关亚临床甲状腺功能减退与糖尿病慢性并发症的相关性探究[J].大家健康,2013,7(6):105-106.
[27] Imig JD, Ryan MJ. Immune and inflammatory role in renal disease[J].Compr Physiol,2013,3(2):957-976. DOI: 10.1002/cphy.c120028.
[28] Hu Y, Liu F, Shen J, et al. Association between serum cystatin C and diabetic peripheral neuropathy: a cross-sectional study of a Chinese type 2 diabetic population[J].Eur J Endocrinol, 2014,171(5):641-648. DOI: 10.1530/EJE-14-0381.
[29] Rizos CV, Elisaf MS, Liberopoulos EN. Effects of thyroid dysfunction on lipid profile[J].Open Cardiovasc Med J,2011,5:76-84.DOI: 10.2174/1874192401105010076.
[30] Rodondi N, den Elzen WP, Bauer DC, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality[J].JAMA,2010,304(12):1365-1374. DOI: 10.1001/jama.2010.1361.
[31] Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction[J].Endocr Rev,2008,29(1):76-131. DOI:10.1210/er.2006-0043.
[32] Klein I, Danzi S. Thyroid disease and the heart[J].Circulation,2007,116(15):1725-1735. DOI:10.1161/CIRCULATIONAHA.106.678326.
[33] 王敬军.糖尿病合并亚临床甲状腺功能减退症的研究进展[J]. 医疗装备,2015(7):43-44 DOI:10.3969/j.issn.1002-2376.2015.07.020.
[34] 田林玉.亚临床甲状腺功能减退症与2型糖尿病及其慢性并发症相关性研究进展[J] 医学综述,2015,21(21):3938-3941. DOI:10.3969/j.issn.1006-2084.2015.21.034.
[35] Dessein PH, Joffe BI, Stanwix AE. Subclinical hypothyroidism is associated with insulin resistance in rheumatoid arthritis[J].Thyroid,2004,14(6):443-446. DOI:10.1089/105072504323150750.
[36] Lee SW, Cho KI, Kim HS,et al. The impact of subclinical hypothyroidism or thyroid autoimmunity on coronary vasospasm in patients without associated cardiovascular risk factors[J].Korean Circ J,2015,45(2):125-130. DOI: 10.4070/kcj.2015.45.2.125.
[37] Mya MM, Aronow WS. Increased prevalence of peripheral arterial disease in older men and women with subclinical hypothyroidism[J].J Gerontol A Biol Sci Med Sci,2003,58(1):68-69.

相似文献/References:

[1]郑少雄.罗格列酮和心血管风险——近期文献解读[J].国际内分泌代谢杂志,2007,(04):231.
[2]凌厉,朱本章.胰岛素类似物安全性研究进展[J].国际内分泌代谢杂志,2007,(04):234.
[3]李颖,刘东方.餐后1小时血糖升高的意义及干预[J].国际内分泌代谢杂志,2007,(04):235.
[4]崔巍,施秉银.内质网应激介导β细胞生存/死亡的研究进展[J].国际内分泌代谢杂志,2007,(04):256.
[5]杨叶虹,胡仁明.SELDI-TOF-MS技术及其在糖尿病研究中的应用[J].国际内分泌代谢杂志,2007,(04):261.
[6]高妍.针对华人糖尿病特点优化降糖方案[J].国际内分泌代谢杂志,2007,(04):269.
[7]杨志霞,郭莹辉,杨永生,等.胰岛素泵和多次皮下注射治疗糖尿病的比较[J].国际内分泌代谢杂志,2007,(04):273.
[8]周建英,马向华.胃旁路术减肥同时改善糖代谢的机制[J].国际内分泌代谢杂志,2007,(04):285.
[9]李翠柳,朱大龙.破译肠道代谢信息,驱动治疗革新[J].国际内分泌代谢杂志,2014,(06):383.[doi:10.3760/cma.j.issn.1673-4157.2014.06.006]
 Li Cuiliu*,Zhu Dalong..Deciphering metabolic messages from the gut drives therapeutic innovation[J].International Journal of Endocrinology and Metabolism,2014,(01):383.[doi:10.3760/cma.j.issn.1673-4157.2014.06.006]
[10]袁捷 姜云生 杜彦丽 王肃.1型糖尿病对小鼠早孕时期子宫肌层结构和细胞增殖的影响[J].国际内分泌代谢杂志,2015,(01):6.[doi:10.3760/cma.j.issn.1673-4157.2015.01.002]
 Yuan JieJiang YunshengDu YanliWang Su.Effects of type 1 diabetes on the muscularis structure and cell proliferation of uterine in mice during early pregnancy[J].International Journal of Endocrinology and Metabolism,2015,(01):6.[doi:10.3760/cma.j.issn.1673-4157.2015.01.002]

备注/Memo

备注/Memo:
通信作者:刘煜,Email:drliuyu@jlu.edu.cn
更新日期/Last Update: 2017-01-20