[1]殷俏,张云良,郭淑芹,等.视黄醇结合蛋白4、超敏C反应蛋白 与糖尿病视网膜病变的关系[J].国际内分泌代谢杂志,2016,36(03):149-152,156.[doi:10.3760/cma.j.issn.1673-4157.2016.03.02]
　Yin Qiao,Zhang Yunliang,Guo Shuqin,et al.Relationship of retinol binding protein 4 and high sensitive C-reactive protein with diabetic retinopathy[J].International Journal of Endocrinology and Metabolism,2016,36(03):149-152,156.[doi:10.3760/cma.j.issn.1673-4157.2016.03.02]
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视黄醇结合蛋白4、超敏C反应蛋白 与糖尿病视网膜病变的关系 ()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年03期
页码:
149-152,156
栏目:
论著
出版日期:
2016-05-20

文章信息/Info

Title:
Relationship of retinol binding protein 4 and high sensitive C-reactive protein with diabetic retinopathy
作者:
殷俏; 张云良; 郭淑芹; 提素芳; 白广琴; 张海江; 杜亚涛; 马朝朋
071000 保定市第一中心医院内分泌一科
Author(s):
Yin Qiao; Zhang Yunliang; Guo Shuqin; Ti Sufang; Bai Guangqin; Zhang Haijiang; Du Yatao; Ma Zhaopeng.
Department of Endocrinology, Baoding NO.1 Central Hospital,Baoding 071000,China
关键词:
视黄醇结合蛋白4;  超敏C反应蛋白;  2型糖尿病;  糖尿病视网膜病变
Keywords:
Retinol binding protein 4;  High-sensitivity C-reactive protein;  Type 2 diabetes mellitus;  Diabetic retinopathy
DOI:
10.3760/cma.j.issn.1673-4157.2016.03.02
摘要:
目的 检测糖尿病视网膜病变(DR)患者血清视黄醇结合蛋白4(RBP4)及超敏C反应蛋白(hs-CRP)水平,探讨RBP4、hs-CRP与DR的相关性。方法 选取保定市第一中心医院内分泌一科住院治疗的123例2型糖尿病患者作为研究对象,其中单纯2型糖尿病(DM)组41例,非增殖性糖尿病视网膜病变(NPDR)组40例,增殖性糖尿病视网膜病变(PDR)组42例。另选取40名正常体检人员作为对照组。应用日立全自动7600生化仪检测所有受试者空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白-胆固醇、高密度脂蛋白-胆固醇、尿酸、同型半胱氨酸水平,电化学发光法测定空腹胰岛素水平,计算稳态模型评估-胰岛素抵抗指数。酶联免疫吸附法测定血清RBP4、hs-CRP水平。Pearson相关分析方法分析上述指标的相关性,Logistic回归分析明确DR的危险因素。结果 与对照组相比,DM组、NPDR组、PDR组RBP4、hs-CRP显著升高,与NPDR组相比,PDR组RBP4、hs-CRP水平显著升高(F=33.224、597.296, P均<0.05)。RBP4与收缩压、舒张压、空腹血糖、稳态模型评估-胰岛素抵抗指数、甘油三酯、总胆固醇、同型半胱氨酸、hs-CRP呈正相关(r=0.172～0.900, P均<0.05),与高密度脂蛋白-胆固醇呈负相关(r=-0.406,P<0.05)。Logistic回归分析发现,收缩压(OR=3.947,95%CI: 1.484～10.502,P=0.006)、空腹血糖(OR=43.494,95%CI:10.490～180.325,P=0.000)、RBP4(OR=2.183,95%CI:1.043～4.57,P=0.038)、hs-CRP(OR=6.802,95%CI:1.791～25.833,P=0.005)为DR的危险因素。结论 DR患者血清RBP4、hs-CRP水平显著升高,两者与DR的发生、发展密切相关。
Abstract:
Objective To detect serum retinol binding protein 4(RBP4)and high-sensitivity C-reactive protein(hs-CRP)in patients with diabetic retinopathy(DR), and to explore the relationship of RBP4 and hs-CRP with DR. Methods A total of 123 patients with type 2 diabetes hospitalized in the Department of Endocrinology in Baoding NO.1 Central Hospital were selected as research subjects, including 41 cases of type 2 diabetes mellitus(DM group), 40 cases of non-proliferative diabetic retinopathy(NPDR group), Forty cases of proliferative diabetic retinopathy(PDR group). Forty cases of normal person were selected as control(NC group). Fasting blood glucose, tiglycerides, total cholesterol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol, uric acid and homocyseine were measured by Hitachi 7600 automatic biochemical analyzer. Fasting insulin were measured by electrochemical luminescence, and homeostasis model assessment-insulin resistance(HOMA-IR)was calculated. RBP4 and hs-CRP were measured by enzyme linked immunosorbent assay. The relationship among the indicators mentioned above was analyzed by Pearson correlation analysis, and Logistic stepwise regression analysis was used to analyze the risk factors of DR. Results Compared with NC group, RBP4,hs-CRP in DM group, NPDR group and PDR group were significantly increased; compared with NPDR group,RBP4 and hs-CRP were significantly higher in PDR group(F=33.224,597.296, all P<0.05).RBP4 was positively correlated with systolic pressure, diastolic blood pressure, fasting blood glucose, HOMA-IR, tiglycerides,total cholesterol, homocyseine and hs-CRP(r=0.172-0.900,all P<0.05), but was negatively correlated with high density lipoprotein-cholesterol(r=-0.406,P<0.05). Logistic stepwise regression analysis showed that systolic pressure(OR=3.947, 95%CI:1.484-10.502,P=0.006), fasting blood glucose(OR=43.494, 95%CI:10.490-180.325,P=0.000),RBP4(OR=2.183, 95%CI:1.043-4.570,P=0.038)and hs-CRP(OR=6.802, 95%CI:1.791-25.833,P=0.005)were risk factors of DR. Conclusion RBP4 and hs-CRP are significantly increased in patients with DR, and are related to the occurrence and development of DR.

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更新日期/Last Update: 2016-05-20