[1]王晓来.糖尿病相关血管钙化[J].国际内分泌代谢杂志,2015,(06):406-408.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.06.012]
 Wang Xiaolai.Diabetes-related vascular calcification[J].International Journal of Endocrinology and Metabolism,2015,(06):406-408.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.06.012]
点击复制

糖尿病相关血管钙化()
分享到:

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年06期
页码:
406-408
栏目:
基础研究
出版日期:
2015-11-20

文章信息/Info

Title:
Diabetes-related vascular calcification
作者:
王晓来
300140 天津第四中心医院内分泌科
Author(s):
Wang Xiaolai
Department of Endocrinology, The Fourth Central Hospital of Tianjin, Tianjin 300140,China
关键词:
糖尿病 血管钙化 流行病学 心血管疾病
Keywords:
Diabetes mellitus Vascular calcification Epidemiology Cardiovascular disease
DOI:
DOI:10.3760/cma.j.issn.1673-4157.2015.06.012
摘要:
多项研究显示糖尿病患者的冠状动脉钙化(CAC)积分升高,CAC进展迅速。糖尿病相关血管钙化与高血糖、维生素D缺乏、胰岛素抵抗、肥胖、贲门上部脂肪、肾脏疾病等多种危险因素相关。心血管疾病(CVD)是导致成人糖尿病患者死亡的主要原因。CAC是斑块负担较好标志,其与糖尿病患者的CVD风险增加显著相关。在糖尿病人群中,CAC的发生及程度可以预测未来心血管事件。
Abstract:
Several studies have shown that in patients with diabetes if the coronary artery calcification(CAC)score increases, the CAC will progress rapidly. Diabetes-related vascular calcification is associated with hyperglycemia, vitamin D deficiency, insulin resistance, obesity, epicardial fat, renal disease and other risk factors. Cardiovascular disease(CVD)is the leading cause of death in adults with diabetes. CAC is a useful marker of plaque burden. It is significantly correlated with the increase of CVD risk in diabetic patients. In diabetic population, the occurrence and level of CAC can be used to predict cardiovascular events in the future.

参考文献/References:

[1] Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics—2012 update: a report from the American Heart Association[J]. Circulation, 2012,125(1):e2-e220. [/br][2] Mehta NN, Krishnamoorthy P, Martin SS, et al. Usefulness of insulin resistance estimation and the metabolic syndrome in predicting coronary atherosclerosis in type 2 diabetes mellitus[J].Am J Cardiol, 2011,107(3):406-411. [/br][3] Dayan A, Narin B, Biteker M, et al. Coronary calcium score, albuminuria and inflammatory markers in type 2 diabetic patients: associations and prognostic implications[J]. Diabetes Res Clin Pract, 2012,98(1):98-103. [/br][4] Lau KK, Wong YK, Chan YH, et al. Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with type 2 diabetes[J]. Cardiovasc Diabetol, 2012,11:101. [/br][5] Malik S, Budoff MJ, Katz R, et al. Impact of subclinical atherosclerosis on cardiovascular disease events in individuals with metabolic syndrome and diabetes: the multi-ethnic study of atherosclerosis[J]. Diabetes Care, 2011,34(10):2285-2290. [/br][6] Boström KI, Jumabay M, Matveyenko A, et al. Activation of vascular bone morphogenetic protein signaling in diabetes mellitus[J]. Circ Res, 2011, 108(4):446-457. [/br][7] Chambers KT, Leone TC, Sambandam N, et al. Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response [J]. J Biol Chem, 2011, 286(13): 11155-11162. [/br][8] Wei Q, Ren X, Jiang Y, et al. Advanced glycation end products accelerate rat vascular calcification through RAGE/oxidative stress[J]. BMC Cardiovasc Disord, 2013,13:13. [/br][9] Brodeur MR, Bouvet C, Bouchard S, et al. Reduction of advanced-glycation end products levels and inhibition of RAGE signaling decreases rat vascular calcification induced by diabetes[J]. PLoS One, 2014, 9(1):e85922. [/br][10] Selisko B, Potisopon S, Agred R, et al. Molecular basis for nucleotide conservation at the ends of the dengue virus genome[J]. PLoS Pathog, 2012, 8(9):e1002912. [/br][11] Snell-Bergeon JK,Chartier-Logan C,Maahs DM, et al. Adults with type 1 diabetes eat a high-fat atherogenic diet that is associated with coronary artery calcium [J]. Diabetologia,2009, 52(5):801-809. [/br][12] Young KA, Snell-Bergeon JK, Naik RG, et al. Vitamin D deficiency and coronary artery calcification in subjects with type 1 diabetes [J]. Diabetes Care, 2011,34(2):454-458. [/br][13] Chang JH, Ro H, Kim S, et al. Study on the relationship between serum 25-hydroxyvitamin D levels and vascular calcification in hemodialysis patients with consideration of seasonal variation in vitamin D levels[J]. Atherosclerosis, 2012,220(2): 563-568. [/br][14] Joergensen C, Reinhard H, Schmedes A, et al. Vitamin D levels and asymptomatic coronary artery disease in type 2 diabetic patients with elevated urinary albumin excretion rate[J]. Diabetes Care, 2012,35(1):168-172. [/br][15] Ong KL, McClelland RL, Rye KA, et al. The relationship between insulin resistance and vascular calcification in coronary arteries, and the thoracic and abdominal aorta: the Multi-Ethnic Study of Atherosclerosis[J]. Atherosclerosis, 2014, 236(2):257-262. [/br][16] Schauer IE, Snell-Bergeon JK, Bergman BC, et al. Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: The CACTI study[J]. Diabetes, 2011,60(1):306-314. [/br][17] Rodrigues TC, Veyna AM, Haarhues MD, et al. Obesity and coronary artery calcium in diabetes: the Coronary Artery Calcification in type 1 Diabetes(CACTI)study[J]. Diabetes Technol Ther, 2011,13(10):991-996. [/br][18] Kim TH, Yu SH, Choi SH, et al. Pericardial fat amount is an independent risk factor of coronary artery stenosis assessed by multidetector-row computed tomography: the Korean Atherosclerosis Study 2[J]. Obesity(Silver Spring), 2011,19(5):1028-1034. [/br][19] Yerramasu A, Dey D, Venuraju S, et al. Increased volume of epicardial fat is an independent risk factor for accelerated progression of sub-clinical coronary atherosclerosis[J]. Atherosclerosis, 2012,220(1):223-230. [/br][20] Weir MR. Recognizing the link between chronic kidney disease and cardiovascular disease[J]. Am J Manag Care, 2011,17(Suppl 15):S396-S402. [/br][21] Berezin AE, Kremzer AA. Circulating osteopontin as a marker of early coronary vascular calcification in type two diabetes mellitus patients with known asymptomatic coronary artery disease[J]. Atherosclerosis, 2013, 229(2):475-481. [/br][22] Zhou S, Fang X, Xin H, et al. Osteoprotegerin inhibits calcification of vascular smooth muscle cell via down regulation of the Notch1-RBP-Jκ/Msx2 signaling pathway[J]. PLoS One, 2013, 8(7):e68987. [/br][23] Currie CJ, Peyrot M, Morgan CL, et al. The impact of treatment non-compliance on mortality in people with type 1 diabetes[J]. J Diabetes Complications,2013,27(3):219-223. [/br][24] Choi YH, Hong YJ, Park IH, et al. Relationship between coronary artery calcium score by multidetector computed tomography and plaque components by virtual histology intravascular ultrasound[J]. J Korean Med Sci, 2011,26(8):1052-1060.

相似文献/References:

[1]郑少雄.罗格列酮和心血管风险——近期文献解读[J].国际内分泌代谢杂志,2007,(04):231.
[2]凌厉,朱本章.胰岛素类似物安全性研究进展[J].国际内分泌代谢杂志,2007,(04):234.
[3]李颖,刘东方.餐后1小时血糖升高的意义及干预[J].国际内分泌代谢杂志,2007,(04):235.
[4]崔巍,施秉银.内质网应激介导β细胞生存/死亡的研究进展[J].国际内分泌代谢杂志,2007,(04):256.
[5]杨叶虹,胡仁明.SELDI-TOF-MS技术及其在糖尿病研究中的应用[J].国际内分泌代谢杂志,2007,(04):261.
[6]高妍.针对华人糖尿病特点优化降糖方案[J].国际内分泌代谢杂志,2007,(04):269.
[7]杨志霞,郭莹辉,杨永生,等.胰岛素泵和多次皮下注射治疗糖尿病的比较[J].国际内分泌代谢杂志,2007,(04):273.
[8]周建英,马向华.胃旁路术减肥同时改善糖代谢的机制[J].国际内分泌代谢杂志,2007,(04):285.
[9]李翠柳,朱大龙.破译肠道代谢信息,驱动治疗革新[J].国际内分泌代谢杂志,2014,(06):383.[doi:10.3760/cma.j.issn.1673-4157.2014.06.006]
 Li Cuiliu*,Zhu Dalong..Deciphering metabolic messages from the gut drives therapeutic innovation[J].International Journal of Endocrinology and Metabolism,2014,(06):383.[doi:10.3760/cma.j.issn.1673-4157.2014.06.006]
[10]袁捷 姜云生 杜彦丽 王肃.1型糖尿病对小鼠早孕时期子宫肌层结构和细胞增殖的影响[J].国际内分泌代谢杂志,2015,(01):6.[doi:10.3760/cma.j.issn.1673-4157.2015.01.002]
 Yuan JieJiang YunshengDu YanliWang Su.Effects of type 1 diabetes on the muscularis structure and cell proliferation of uterine in mice during early pregnancy[J].International Journal of Endocrinology and Metabolism,2015,(06):6.[doi:10.3760/cma.j.issn.1673-4157.2015.01.002]

备注/Memo

备注/Memo:
作者单位:300140 天津第四中心医院内分泌科
更新日期/Last Update: 2015-11-20