[1]曹萌 陈堃 茅晓东 刘超.限食治疗糖尿病肾病的研究进展[J].国际内分泌代谢杂志,2015,(06):395-397.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.06.009]
　Cao Meng,Chen Kun,Mao Xiaodong,et al.Effects of diet restriction on diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(06):395-397.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.06.009]
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限食治疗糖尿病肾病的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年06期
页码:
395-397
栏目:
临床研究
出版日期:
2015-11-20

文章信息/Info

Title:
Effects of diet restriction on diabetic nephropathy
作者:
曹萌 陈堃 茅晓东 刘超
210028 南京,中国中医科学院江苏分院,南京中医药大学附属中西医结合医院内分泌代谢病院区
Author(s):
Cao Meng; Chen Kun; Mao Xiaodong; Liu Chao
Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Jiangsu Branch of China Academy of Chinese Medical Science, Nanjing 210028, China
关键词:
糖尿病;  糖尿病肾病;  热量限制;  蛋白限制;  限食模拟剂
Keywords:
Diabetes mellitus;  Diabetic nephropathy;  Calorie restriction;  Protein restriction;  Analogue of calorie restriction
DOI:
DOI:10.3760/cma.j.issn.1673-4157.2015.06.009
摘要:
糖尿病肾病是一类十分常见的糖尿病微血管并发症,也是糖尿病致残、致死的主要原因之一。大量的基础和临床研究证实,不同的饮食限制如低蛋白限食、低热量限食及限食模拟剂能够减少蛋白尿的产生、提高肾小球滤过率,防止肾结构改变,以延缓糖尿病肾病的进展,但其具体机制是否与增强自噬、抗氧化应激、抗凋亡相关尚待进一步研究。
Abstract:
Diabetic nephropathy is one of the most common complications of diabetic microangiopathy and the leading causes of death in patients with diabetes. Clinical and basic experiments demonstrated that different types such as calorie or protein restriction and analogue of calorie restriction can reduce the albuminuria, improve glomerular filtration rate, prevent the destruction of the renal construction and delay the progression of diabetic nephropathy.However, the mechanisms of diet restriction,which may be associated with enhanced autophagy or anti-oxidative stress and anti-apoptosis,still need further research.

参考文献/References:

[1] Stanton RC. Frontiers in diabetic kidney disease: introduction[J]. Am J Kidney Dis, 2014, 63(2 Suppl 2): S1-S2. [/br][2] Speakman JR,Mitchell SE.Caloric restriction[J].Mol Aspects Med, 2011, 32(3): 159-221. [/br][3] Varady KA, Hellerstein MK. Alternate-day fasting and chronic disease prevention: a review of human and animal trials[J]. Am J Clin Nutr, 2007, 86(1): 7-13. [/br][4] Ajala O, English P, Pinkney J. Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes[J]. Am J Clin Nutr, 2013, 97(3):505-516. [/br][5] Velázquez López L,Sil Acosta MJ, Goycochea Robles MV, et al. Effect of protein restriction diet on renal function and metabolic control in patients with type 2 diabetes: a randomized clinical trial[J]. Nutr Hosp, 2008, 23(2): 141-147. [/br][6] Koya D, Haneda M, Inomata S, et al. Long-term effect of modification of dietary protein intake on the progression of diabetic nephropathy: a randomised controlled trial[J].Diabetologia, 2009, 52(10): 2037-2045. [/br][7] Nezu U, Kamiyama H, Kondo Y, et al. Effect of low-protein diet on kidney function in diabetic nephropathy: meta-analysis of randomised controlled trials[J].BMJ Open,2013,3(5): e002934. [/br][8] Hansen HP, Tauber-Lassen E, Jensen BR, et al. Effect of dietary protein restriction on prognosis in patients with diabetic nephropathy[J]. Kidney Int, 2002, 62(1): 220-228. [/br][9] Feiten SF, Draibe SA, Watanabe R, et al. Short-term effects of a very-low-protein diet supplemented with ketoacids in nondialyzed chronic kidney disease patients[J].Eur J Clin Nutr, 2005, 59(1): 129-136. [/br][10] Mitch WE. Beneficial responses to modified diets in treating patients with chronic kidney disease[J]. Kidney Int Suppl, 2005,(94): S133-S135. [/br][11] Lezcano EJ, Iñigo P, Larraga AM, et al. Caloric restriction or telmisartan control dyslipidemia and nephropathy in obese diabetic Zücker rats[J]. Diabetol Metab Syndr, 2014, 6(1): 10. [/br][12] Nangaku M. Energy policy of the kidney: launch of AMPK as a novel therapeutic target[J]. Am J Physiol Renal Physiol, 2013, 305(7): F977-F978. [/br][13] Dutra MF, Bristot IJ, Batassini C, et al. Effects of chronic caloric restriction on kidney and heart redox status and antioxidant enzyme activities in Wistar rats[J].BMB Rep, 2012, 45(11): 671-676. [/br][14] Kitada M, Kume S, Takeda-Watanabe A, et al. Sirtuins and renal diseases: relationship with aging and diabetic nephropathy[J]. Clin Sci(Lond), 2013, 124(3): 153-164. [/br][15] Lempiäinen J, Finckenberg P, Mervaala EE, et al. Caloric restriction ameliorates kidney ischaemia/reperfusion injury through PGC-1α-eNOS pathway and enhanced autophagy[J].Acta Physiol(Oxf), 2013, 208(4): 410-421. [/br][16] Tikoo K,Lodea S,Karpe PA,et al.Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy[J]. Biochem Biophys Res Commun, 2014, 450(4): 1581-1586. [/br][17] Cui J, Shi S, Sun X, et al. Mitochondrial autophagy involving renal injury and aging is modulated by caloric intake in aged rat kidneys[J]. PLoS One, 2013, 8(7): e69720.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81270861) 作者单位:210028 南京,中国中医科学院江苏分院,南京中医药大学附属中西医结合医院内分泌代谢病院区 通信作者:刘超,Email:liuchao@jsatcm.com
更新日期/Last Update: 2015-11-20