[1]任惠珠,王珊珊,郑妙艳,等.肾小球基底膜中胶原的合成、降解与糖尿病肾病[J].国际内分泌代谢杂志,2015,(04):252-254.[doi:10.3760/cma.j.issn.1673-4157.2015.04.010]
 Ren Huizhu,Wang Shanshan,Zheng Miaoyan,et al.Synthesis and degradation of collagen in glomerular basement membrane and their associations with diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(04):252-254.[doi:10.3760/cma.j.issn.1673-4157.2015.04.010]
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肾小球基底膜中胶原的合成、降解与糖尿病肾病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年04
页码:
252-254
栏目:
糖尿病肾病专栏
出版日期:
2015-07-20

文章信息/Info

Title:
Synthesis and degradation of collagen in glomerular basement membrane and their associations with diabetic nephropathy
作者:
任惠珠王珊珊郑妙艳单春艳
300070 天津医科大学代谢病医院内分泌研究所,卫生部激素与发育重点实验室
Author(s):
Ren HuizhuWang ShanshanZheng MiaoyanShan Chunyan.
Key Laboratory of Hormones and Development(Ministry of Health),The Metabolic Disease Hospital & Tianjin Institute of Endocrinology,Tianjin Medical University,Tianjin 300070,China Corresponding author:Shan Chunyan,Email:chunyanshan@hotmail.com
关键词:
肾小球基底膜胶原合成降解糖尿病肾病
Keywords:
Glomerular basement membraneCollagenSynthesisDegradationDiabetic nephropathy
DOI:
10.3760/cma.j.issn.1673-4157.2015.04.010
摘要:
糖尿病肾病是终末期肾病的主要原因,发病机制复杂。肾小球基底膜增厚及系膜区细胞外基质增生是主要的病理特点,胶原合成增多、降解减少是肾脏病理改变的主要原因。研究肾小球滤过屏障的生理功能与损伤机制,对深入了解糖尿病肾病的发生、发展尤为重要。
Abstract:
Diabetic nephropathy,with a complicated pathogenesis, has become the major cause of end stage renal disease. The thickening of glomerular basement membrane and hyperplasia of mesangial area of extracellular matrix are the main pathological features. Increased synthesis and decreased degradation of collagen are major causes of renal pathological changes. Researches of the physiological function and the injury mechanism of glomerular filtration barrier are particularly important for further understanding of the occurrence and development of diabetic nephropathy.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81473472)   通信作者:单春艳,Email: chunyanshan@hotmail.com
更新日期/Last Update: 2015-07-20