[1]任慧雯,王秋月.Vasohibin-1与糖尿病肾病[J].国际内分泌代谢杂志,2015,(04):246-247,251.[doi:10.3760/cma.j.issn.1673-4157.2015.04.008]
　Ren Huiwen,Wang Qiuyue..Vasohibin-1 and diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(04):246-247,251.[doi:10.3760/cma.j.issn.1673-4157.2015.04.008]
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Vasohibin-1与糖尿病肾病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年04
页码:
246-247,251
栏目:
糖尿病肾病专栏
出版日期:
2015-07-20

文章信息/Info

Title:
Vasohibin-1 and diabetic nephropathy
作者:
任慧雯; 王秋月
110001　沈阳，中国医科大学附属第一医院内分泌与代谢病科 　　
Author(s):
Ren Huiwen; Wang Qiuyue.
Department of Endocrinology and Metabolism，The First Affiliated Hospital，China Medical University，Shenyang 110001，China Corresponding author：Wang Qiuyue，Email：wqycmu@163.com
关键词:
糖尿病肾病; Vasohibin-1; 血管内皮生长因子
Keywords:
Diabetic nephropathy; Vasohibin-1; Vascular endothelial growth factor
DOI:
10.3760/cma.j.issn.1673-4157.2015.04.008
摘要:
Vasohibin-1（VASH-1） 是一种以负反馈机制调节血管生成的内皮源性分泌蛋白。它能够以负反馈作用机制抑制血管内皮生长因子的作用，参与多种抗血管生成作用。作为机体的自我防御因子，VASH-1能够维持血管内皮的完整性，从而起到抵御糖尿病微血管并发症的作用。近年研究表明，VASH-1对肾小球内皮细胞和系膜细胞具有缓解微血管损害、调节炎性反应、延缓肾间质纤维化等重要功能，对糖尿病肾病具有重要的保护作用，可能成为糖尿病肾病早期治疗的一个新靶点。
Abstract:
Vasohibin-1 （VASH-1） is an endothelium-derived secreted protein， which regulates angiogenesis by means of negative feedback modulation. VASH-1 suppresses the effects of vascular endothelial growth factor with negative feedback mechanism，and involve in a variety of anti-angiogenic effects. As a self- defense factor of the body，VASH-1 maintains the integrity of vascular endothelium，which plays a role in preventing microvascular complications of diabetes. Recent studies have found that VASH-1 could relieve microvascular damage，regulate inflammation，and delay renal interstitial fibrosis in glomerular endothelial and mesangial cells. Therefore，VASH-1 plays an important protective role in diabetic nephropathy，and may become a new target for the treatment of diabetic nephropathy.

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备注/Memo

备注/Memo:
基金项目：辽宁省科技攻关计划项目（2011225017）；沈阳市科技攻关计划项目（F11-262-9-06） 通信作者：王秋月，Email：wqycmu@163.com
更新日期/Last Update: 2015-07-20