[1]李素芬,韩颖,石节丽,等.MicroRNAs对胰岛β细胞功能的影响[J].国际内分泌代谢杂志,2015,(03):193-195.[doi:10.3760/cma.j.issn.1673-4157.2015.03.014]
　Li Sufen,Han Ying,Shi Jieli,et al.Effects of microRNAs on islet β cell function[J].International Journal of Endocrinology and Metabolism,2015,(03):193-195.[doi:10.3760/cma.j.issn.1673-4157.2015.03.014]
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MicroRNAs对胰岛β细胞功能的影响()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年03
页码:
193-195
栏目:
综述
出版日期:
2015-05-20

文章信息/Info

Title:
Effects of microRNAs on islet β cell function
作者:
李素芬; 韩颖; 石节丽; 田秀标; 徐福娟; 高鹏飞; 刘艳
300280　天津海滨人民医院内分泌科
Author(s):
Li Sufen; Han Ying; Shi Jieli; Tian Xiubiao; Xu Fujuan; Gao Pengfei; Liu Yan.
Department of Endocrinology，The Seaside People's Hospital of Tianjin，Tianjin 300280，China
关键词:
糖尿病; 胰岛β细胞; microRNA
Keywords:
Diabetes mellitus; Islet β cell; MicroRNA
DOI:
10.3760/cma.j.issn.1673-4157.2015.03.014
摘要:
近年已有大量研究证实，在β细胞功能调节中，microRNA起重要作用。MicroRNA是基因表达的负调控因子，在β细胞的增殖、生存方面起关键作用。特定microRNA水平的改变与β细胞代偿功能相关，促进β细胞存活和发挥作用的激素或生物活性肽可调节microRNA水平。相反，细胞因子、高脂血症、高血糖和氧化型低密度脂蛋白引起的microRNA的表达修饰，可以促进β细胞功能衰竭和凋亡。
Abstract:
Recent studies have emphasized the instrumental role of microRNAs in the control of β cell function. MicroRNAs are negative regulators of gene expression，and are pivotal for the control of β cell proliferation，function，and survival. Changes in specific microRNA levels，which have been associated with β cell compensation，are triggered by hormones or bioactive peptides that promote β cell survival and function. Conversely，modifications of other specific microRNAs contribute to β cell dysfunction and death elicited by diabetogenic factors including cytokines，chronic hyperlipidemia，hyperglycemia，and oxidized low density lipoprotein.

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更新日期/Last Update: 2015-05-20