[1]赵娅,万沁.类胰蛋白酶与代谢综合征[J].国际内分泌代谢杂志,2015,(03):190-192.[doi:10.3760/cma.j.issn.1673-4157.2015.03.013]
　Zhao Ya,Wan Qin..Tryptase and metabolic syndrome[J].International Journal of Endocrinology and Metabolism,2015,(03):190-192.[doi:10.3760/cma.j.issn.1673-4157.2015.03.013]
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类胰蛋白酶与代谢综合征()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年03
页码:
190-192
栏目:
综述
出版日期:
2015-05-20

文章信息/Info

Title:
Tryptase and metabolic syndrome
作者:
赵娅; 万沁
646000　泸州医学院附属医院内分泌科
Author(s):
Zhao Ya; Wan Qin.
Department of Endocrinology，The Affiliated Hospital of Luzhou Medical College，Luzhou 646000，China Corresponding author：Wan Qin，Email：wanqin3@163.com
关键词:
类胰蛋白酶; 代谢综合征; 糖尿病
Keywords:
Tryptase; Metabolic syndrome; Diabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2015.03.013
摘要:
代谢综合征是心血管疾病的多种代谢危险因素在个体内集结的状态，主要包括肥胖、糖尿病或糖调节受损、血脂紊乱以及高血压。近来研究发现，代谢综合征的发病与机体慢性炎性反应状态相关。类胰蛋白酶是肥大细胞中含量最丰富的颗粒蛋白，也是一种重要的炎性介质，它可通过促进炎性反应细胞的聚集、细胞凋亡、新生血管形成、基质蛋白重塑等多种机制参与代谢综合征的发生与发展。
Abstract:
Metabolic syndrome is the clustering of cardiovascular risk factors in body，including obesity，diabetes or impaired glucose tolerance，dyslipidemia，and hypertension. Recent studies suggest that the onset of metabolic syndrome is associated with the state of chronic inflammation. Tryptase is the most abundant grain protein contents in mast cells，and also the important inflammatory mediator，it can participate in the occurrence and development of metabolic syndrome by inducing inflammatory cell recruitment，cell apoptosis， angiogenesis，and matrix protein remodeling.

参考文献/References:

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备注/Memo

备注/Memo:
通信作者：万沁，Email：wanqin3@163.com
更新日期/Last Update: 2015-05-20