[1]李春睿,王静,陈峰,等.GLP-1受体激动剂对糖尿病患者肾功能的影响[J].国际内分泌代谢杂志,2014,(06):401-403.[doi:10.3760/cma.j.issn.1673-4157.2014.06.011]
 Li Chunrui*,Wang Jing,Chen Feng,et al.Effects of GLP-1 receptor agonists on renal function of diabetics[J].International Journal of Endocrinology and Metabolism,2014,(06):401-403.[doi:10.3760/cma.j.issn.1673-4157.2014.06.011]
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GLP-1受体激动剂对糖尿病患者肾功能的影响()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年06期
页码:
401-403
栏目:
综述
出版日期:
2014-12-20

文章信息/Info

Title:
Effects of GLP-1 receptor agonists on renal function of diabetics
作者:
李春睿王静陈峰刘超
262600 潍坊市市直机关医院内分泌科(李春睿,王静,陈峰); 210028 南京中医药大学附属中西医结合医院内分泌代谢病院区(刘超)
Author(s):
Li Chunrui*Wang JingChen Feng Liu Chao.
*Department of Endocrinology, Weifang Municipal Official Hospital, Weifang 262600, China
关键词:
GLP-1受体 GLP-1受体激动剂 糖尿病 肾功能
Keywords:
GLP-1 receptor GLP-1 receptor agonist Diabetes mellitus Renal function
DOI:
10.3760/cma.j.issn.1673-4157.2014.06.011
摘要:
作为一种新型的降糖药物,胰高血糖素样肽(GLP)-1受体激动剂可有效降低血糖、减轻体重。此外,该药可能还具有改善糖尿病患者肾功能,调节水、盐排泄、降低血压等作用。并且,这一保护作用可能是通过其抗炎、抗氧化应激、改善内皮细胞功能实现的。但是,该药物不适用于严重肾脏病变的患者,因此,它是否可以用于预防和治疗糖尿病肾病,目前尚无定论。
Abstract:
As a new antidiabetic medicine, glucagon-like peptide(GLP)-1 receptor agonist can effectively lower blood glucose and reduce body weight. In addition, it may also improve renal function of diabetic patients, regulate water and salt excretion as well as lower blood pressure. This effect may depend on its anti-inflammation, anti-oxidative stress and endothelial function improvement. However, GLP-1 receptor agonist is not suitable for patients with severely injured renal function, and whether or not it can be used to prevent and treat diabetic nephropathy remains unclear.

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更新日期/Last Update: 2014-12-20