[1]吕丹,陈树春,李晓思.白色脂肪棕色化及其调控因素[J].国际内分泌代谢杂志,2014,(05):321-323.[doi:10.3760/cma.j.issn.1673-4157.2014.05.009]
 Lyu Dan*,Chen Shuchun,Li Xiaosi..Browning of white adipose tissue and its regulating factors[J].International Journal of Endocrinology and Metabolism,2014,(05):321-323.[doi:10.3760/cma.j.issn.1673-4157.2014.05.009]
点击复制

白色脂肪棕色化及其调控因素()
分享到:

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年05期
页码:
321-323
栏目:
综述
出版日期:
2014-10-31

文章信息/Info

Title:
Browning of white adipose tissue and its regulating factors
作者:
吕丹陈树春李晓思
050017 石家庄,河北医科大学研究生学院(吕丹,李晓思); 050051 河北省人民医院内分泌一科(陈树春)
Author(s):
Lyu Dan*Chen ShuchunLi Xiaosi.
*Graduate School of Hebei Medical University,Shijiazhuang 050017,China Corresponding author: Chen Shuchun,Email:guang6701@sina.com
关键词:
白色脂肪组织 棕色脂肪组织 白色脂肪棕色化
Keywords:
White adipose tissue Brown adipose tissue White adipose tissue browning
DOI:
10.3760/cma.j.issn.1673-4157.2014.05.009
摘要:
近年,对脂肪组织的起源、分化、作用及调节的认识有了新的进展。体内的白色脂肪组织负责储存能量并分泌一些脂肪因子参与各种代谢性疾病的发生,而棕色脂肪组织主要负责产热和消耗能量。因此,“白色脂肪棕色化”对肥胖及许多相关疾病有着巨大的治疗潜力,可为这些疾病的治疗提供新的选择。“白色脂肪棕色化”这一过程受多种因素调控,如多种转录调节剂、蛋白质和激素等,因此未来可通过干预这些调控因素来研究相关疾病的新治疗方法。
Abstract:
Recently, great progress has been achieved in the understanding of the origin, differentiation, function, and regulation of adipose tissue. While white adipose tissue in the body is responsible for storing energy and secreting adipocytokines which involved in various metabolic diseases, brown adipose tissue is mainly responsible for producing heat and energy consumption. So 'browning of white adipose tissue' has great potential to be used in the treatment of obesity and many related diseases, which can provide new options for the treatment of these diseases in the future. The process of 'browning of white adipose tissue' is regulated by many factors, such as a variety of transcriptional regulators, proteins and hormones, so new intervention method may be achieved by targeting these regulatory factors.

参考文献/References:

[1] Ntaios G, Gatselis NK, Makaritsis K, et al. Adipokines as mediators of endothelial function and atherosclerosis[J].Atherosclerosis, 2013, 227(2): 216-221.
[2] Adamczak M, Wiecek A. The adipose tissue as an endocrine organ[J].Semin Nephrol, 2013, 33(1): 2-13.
[3] Cao H. Adipocytokines in obesity and metabolic disease[J].J Endocrinol, 2014, 220(2): 47-59.
[4] DeClercq V, Enns JE, Yeganeh A, et al. Modulation of cardiovascular function by adipokines[J].Cardiovasc Hematol Disord Drug Targets, 2013, 13(1): 59-72.
[5] Mattu HS, Randeva HS. Role of adipokines in cardiovascular disease[J].J Endocrinol, 2013, 216(1): 17-36.
[6] Giralt M, Villarroya F. White, brown, beige/brite: different adipose cells for different functions[J].Endocrinology, 2013, 154(9): 2992-3000.
[7] Vijgen GH, Bouvy ND, Teule GJ, et al. Increase in brown adipose tissue activity after weight loss in morbidly obese subjects[J].J Clin Endocrinol Metab, 2012, 97(7): 1229-1233..
[8] Yoneshiro T, Aita S, Matsushita M, et al. Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans[J].Obesity(Silver Spring),2011,19(9):1755-1760.
[9] Bartelt A, Bruns OT, Reimer R, et al. Brown adipose tissue activity controls triglyceride clearance[J].Nat Med, 2011, 17(2): 200-205.
[10] van der Veen DR, Shao J, Chapman S, et al. A diurnal rhythm in glucose uptake in brown adipose tissue revealed by in vivo PET-FDG imaging[J].Obesity(Silver Spring), 2012, 20(7): 1527-1529.
[11] Boss O, Farmer SR. Recruitment of brown adipose tissue as a therapy for obesity-associated diseases[J].Front Endocrinol(Lausanne), 2012,3:14.
[12] Schulz TJ, Tseng YH. Brown adipose tissue: development, metabolism and beyond[J].Biochem J, 2013, 453(2): 167-178.
[13] Qiang L, Wang L, Kon N, et al. Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of PPARgamma[J].Cell, 2012, 150(3): 620-632.
[14] Rajakumari S, Wu J, Ishibashi J, et al. EBF2 determines and maintains brown adipocyte identity[J].Cell Metab,2013,17(4): 562-574.
[15] Zafrir B. Brown adipose tissue: research milestones of a potential player in human energy balance and obesity[J].Horm Metab Res, 2013, 45(11): 774-785.
[16] Vegiopoulos A, Muller-Decker K, Strzoda D, et al. Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes[J].Science,2010,328(5982):1158-1161.
[17] Bostrom P, Wu J, Jedrychowski MP, et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis[J].Nature, 2012, 481(7382): 463-468.
[18] Chartoumpekis DV, Habeos IG, Ziros PG, et al. Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21[J].Mol Me, 2011, 17(7-8): 736-740.
[19] Fisher FM,Kleiner S,Douris N, et al.FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis[J].Genes Dev,2012,26(3): 271-281.
[20] Schulz TJ,Huang TL,Tran TT,et al. Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat[J].Proc Natl Acad Sci U S A,2011,108(1):143-148.

相似文献/References:

[1]王亚梅,沈捷,陈家伟,等.β_3肾上腺素能受体激动剂对人体和动物脂肪组织的作用[J].国际内分泌代谢杂志,2007,(04):295.
[2]王雪 朱惠娟 龚凤英.棕色脂肪因子与代谢性疾病[J].国际内分泌代谢杂志,2019,39(06):409.[doi:10.3760/cma.j.issn.1673-4157.2019.06.012]
 Wang Xue,Zhu Huijuan,Gong Fengying.Relationship between brown adipocytokine and metabolic diseases[J].International Journal of Endocrinology and Metabolism,2019,39(05):409.[doi:10.3760/cma.j.issn.1673-4157.2019.06.012]
[3]王瑜 崔景秋.肠道菌群与白色脂肪棕色化及棕色脂肪活化的关系[J].国际内分泌代谢杂志,2020,40(03):188.[doi:10.3760/cma.j.issn.1673-4157.2020.03.010]
 Wang Yu,Cui Jingqiu.Relationship between gut microbiota and browning of white adipose tissue, activation of brown adipose tissue[J].International Journal of Endocrinology and Metabolism,2020,40(05):188.[doi:10.3760/cma.j.issn.1673-4157.2020.03.010]

备注/Memo

备注/Memo:
通信作者:陈树春,Email:guang6701@sina.com
更新日期/Last Update: 2014-09-20