[1]李亚兰,项洁,卜瑞芳.1型糖尿病的DiaPep277免疫治疗[J].国际内分泌代谢杂志,2014,(03):169-171.[doi:10.3760/cma.j.issn.1673-4157.2014.03.007]
 Li Yalan,Xiang Jie,Bu Ruifang..Immunotherapy with DiaPep277 peptide in type 1 diabetes[J].International Journal of Endocrinology and Metabolism,2014,(03):169-171.[doi:10.3760/cma.j.issn.1673-4157.2014.03.007]
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1型糖尿病的DiaPep277免疫治疗()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年03期
页码:
169-171
栏目:
综述(临床研究)
出版日期:
2014-06-30

文章信息/Info

Title:
Immunotherapy with DiaPep277 peptide in type 1 diabetes
作者:
李亚兰项洁卜瑞芳
214023 无锡市人民医院内分泌科   
Author(s):
Li YalanXiang JieBu Ruifang.
Department of Endocrinology,Wuxi City People's Hospital,Wuxi 214023,China Corresponding author:Bu Ruifang,Email:brfang2003@yahoo.com.cn
关键词:
DiaPep277免疫调节1型糖尿病
Keywords:
DiaPep277ImmunomodulationType 1 diabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2014.03.007
摘要:
1型糖尿病(T1DM)的病理基础是胰岛β细胞的自身免疫性破坏,因此阻止该免疫进程对预防或治疗T1DM尤为重要。DiaPep277是一种由24个氨基酸组成的肽段,衍生于热休克蛋白60(HSP60)的C-末端区域。研究证明,它对糖尿病动物模型的自身免疫性T细胞具有免疫调节作用。临床研究表明,DiaPep277对初发T1DM患者的胰岛β细胞有保护作用,并具有安全性。
Abstract:
Type 1 diabetes mellitus(T1DM) is characterized by the autoimmune destruction of islet β cells.Blocking the immune process is important for prevention and treatment of T1DM.DiaPep277 is composed of 24 amino acids derived from the C-terminal region of heat shock proteins 60(HSP60) and manufactured as a synthetic peptide. DiaPep277 has an immune modulatory effect on T cells in animal models of diabetes.The results of the clinical trials indicate that DiaPep277 is safe and can preserve β cell function in patients with newly diagnosed T1DM.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目: 江苏省自然科学基金资助项目(BK2011177) 通信作者:卜瑞芳,Email:brfang2003@yahoo.com.cn
更新日期/Last Update: 2014-05-20