[1]袁琴,王秋月.Notch信号转导通路与糖尿病肾病的关系[J].国际内分泌代谢杂志,2014,(02):127-130.[doi:10.3760/cma.j.issn.1673-4157.2014.02.016]
 Yuan Qin,Wang Qiuyue..Relationship between Notch signaling and diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2014,(02):127-130.[doi:10.3760/cma.j.issn.1673-4157.2014.02.016]
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Notch信号转导通路与糖尿病肾病的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年02期
页码:
127-130
栏目:
综述
出版日期:
2014-04-30

文章信息/Info

Title:
Relationship between Notch signaling and diabetic nephropathy
作者:
袁琴王秋月
110001 沈阳,中国医科大学附属第一医院内分泌科   
Author(s):
Yuan QinWang Qiuyue.
Department of Endocrinology,The First Affiliated Hospital of China Medical University,Shenyang 110001,China Corresponding author:Wang Qiuyue,Email:wqycmu@163.com
关键词:
糖尿病肾病 Notch通路信号转导
Keywords:
Diabetic nephropathyNotch signalingSignal transduction
DOI:
10.3760/cma.j.issn.1673-4157.2014.02.016
摘要:
糖尿病肾病(DN)是糖尿病常见微血管病变之一,高糖状态、高血压、免疫炎性反应等因素均可导致肾功能减退,加速DN的发生和发展。Notch信号转导通路作为在进化上高度保守的信号系统,可通过调节细胞间的相互作用,影响细胞、组织及器官的分化和发育。研究表明,在DN中Notch信号转导通路明显活化,并通过影响血管生成和胰腺内分泌及外分泌细胞发生、介导肾小球功能损伤和足细胞凋亡、促进肾小管间质损伤和纤维化进展,影响DN的进展。阻断Notch通路可能成为DN治疗的新靶点。
Abstract:
Diabetic nephropathy(DN) is one of the most common microvascular complications of diabetes. Hyperglycemia,hypertension and immune-inflammation can cause the decline of renal function,which can in turn promote the development of DN. Notch signaling is an evolutionarily conserved signal pathway which regulates the cell-to-cell communication,thus to influence the differentiation and development of cell,tissue and organ. Researches have shown that Notch signaling is activated in DN and then promote the development of DN by affecting angiogenesis and genesis of pancreatic endocrine and exocrine cells,mediating functional injury of glomerular cells and podocyte apoptosis,and promoting tubular interstitial injury and fibrosis development. Blocking Notch signaling may be a new target for treatment of DN.

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备注/Memo

备注/Memo:
基金项目:辽宁省科技攻关计划项目(2011225017);沈阳市科技攻关项目(F11-262-9-06);辽宁省“百千万人才工程”资助项目(2011年) 通信作者:王秋月,Email:wqycmu@163.com
更新日期/Last Update: 2014-03-20